| UniProt/SwissProt ID: | CXCR3_HUMAN |
| Description: | chemokine (C-X-C motif) receptor 3 [Source:HGNC Symbol;Acc:4540] |
| Location: | chrX q13.1 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y271 | LCWTPyHLVVL | 7tm_1; TM | PhosphoSitePlus |
| Y308 | TSGLGyMHCCL | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| CXCR3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362797 | D7N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362797 | R167H | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CXCR3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CXCR3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CXCL9_HUMAN | CXCR3_HUMAN | ligand -> receptor | HPMR |
| CXL10_HUMAN | CXCR3_HUMAN | ligand -> receptor | HPMR |
| SDF1_HUMAN | CXCR3_HUMAN | ligand -> receptor | HPMR |
| CXL11_HUMAN | CXCR3_HUMAN | ligand -> receptor | HPMR |
| CXCR3_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| CXCR3_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| CXCR3_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| CXCR3_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| CXL11_HUMAN | CXCR3_HUMAN | other | KEGG |
| CXL10_HUMAN | CXCR3_HUMAN | other | KEGG |
| CXCL9_HUMAN | CXCR3_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04062 | Chemokine signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004950 | chemokine receptor activity | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0006935 | chemotaxis | TAS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007204 | elevation of cytosolic calcium ion concentration | IEA | biological_process |
| GO:0070098 | chemokine-mediated signaling pathway | IEA | biological_process |
| GO:0004950 | chemokine receptor activity | TAS | molecular_function |
| GO:0019722 | calcium-mediated signaling | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0016494 | C-X-C chemokine receptor activity | IEA | molecular_function |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0010818 | T cell chemotaxis | IEA | biological_process |
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0019956 | chemokine binding | IPI | molecular_function |