| UniProt/SwissProt ID: | SSR3_HUMAN |
| Description: | somatostatin receptor 3 [Source:HGNC Symbol;Acc:11332] |
| Location: | chr22 q13.1 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T348 | GPPEKtEEEDE | HPRD | |
| Y142 | MSVDRyLAVVH | 7tm_1 | PhosphoSitePlus |
| T341 | RSQEPtVGPPE | PhosphoSitePlus | |
| S332 | VLLRPsRRVRS | PhosphoSitePlus; HPRD | |
| S337 | SRRVRsQEPTV | PhosphoSitePlus; HPRD | |
| Y303 | VVALPyANSCA | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| SSR3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000330138 | P289H | COSMIC | Lung Cancer | 20668451 | ENSP00000330138 | R333H | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| SSR3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SSR3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CORT_HUMAN | SSR3_HUMAN | ligand -> receptor | HPMR |
| SMS_HUMAN | SSR3_HUMAN | ligand -> receptor | HPMR |
| SSR3_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| SSR3_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| SSR3_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| SSR3_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0071392 | cellular response to estradiol stimulus | IEA | biological_process |
| GO:0031513 | nonmotile primary cilium | ISS | cellular_component |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0007267 | cell-cell signaling | TAS | biological_process |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0030900 | forebrain development | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0021549 | cerebellum development | IEA | biological_process |
| GO:0008628 | hormone-mediated apoptotic signaling pathway | TAS | biological_process |
| GO:0004994 | somatostatin receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0038170 | somatostatin signaling pathway | TAS | biological_process |
| GO:0031513 | nonmotile primary cilium | IEA | cellular_component |
| GO:0042594 | response to starvation | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007283 | spermatogenesis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0071385 | cellular response to glucocorticoid stimulus | IEA | biological_process |