| UniProt/SwissProt ID: | GALR2_HUMAN |
| Description: | galanin receptor 2 [Source:HGNC Symbol;Acc:4133] |
| Location: | chr17 q25.1 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y292 | VNPIVyALVSK | HPRD | |
| Y213 | ARTLRyLWRAV | phosphoELM | |
| Y160 | LFSGPyLSYYR | 7tm_1; TM | PhosphoSitePlus |
| Y164 | PYLSYyRQSQL | 7tm_1 | PhosphoSitePlus |
| Y213 | ARTLRyLWRAV | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| GALR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000329684 | T138M | COSMIC | Head and Neck Cancer | 21984974 |
| Differential expressed protein |
| GALR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GALR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GALP_HUMAN | GALR2_HUMAN | ligand -> receptor | HPMR |
| GCSAM_HUMAN | GALR2_HUMAN | ligand -> receptor | HPMR |
| GALR2_HUMAN | GNA12_HUMAN | GPCR -> Gprotein | gpDB |
| GALR2_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| GALR2_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| GALR2_HUMAN | GNA13_HUMAN | GPCR -> Gprotein | gpDB |
| GALR2_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| GALR2_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| GALR2_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| GALR2_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0007631 | feeding behavior | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007275 | multicellular organismal development | TAS | biological_process |
| GO:0007611 | learning or memory | TAS | biological_process |
| GO:0006936 | muscle contraction | TAS | biological_process |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0031175 | neuron projection development | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007586 | digestion | TAS | biological_process |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled rec | TAS | biological_process |
| GO:0004966 | galanin receptor activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |