| UniProt/SwissProt ID: | HRH4_HUMAN |
| Description: | histamine receptor H4 [Source:HGNC Symbol;Acc:17383] |
| Location: | chr18 q11.2 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S208 | KRDHLsRCQSH | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| HRH4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000256906 | A273S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000256906 | R229S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000256906 | Y358F | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| HRH4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HRH4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HDC_HUMAN | HRH4_HUMAN | ligand -> receptor | HPMR |
| HRH4_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| HRH4_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| HRH4_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| HRH4_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004969 | histamine receptor activity | NAS | molecular_function |
| GO:0008150 | biological_process | ND | biological_process |
| GO:0004969 | histamine receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |