Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DRD3_HUMAN
Description:dopamine receptor D3 [Source:HGNC Symbol;Acc:3024]
Location:chr3 q13.31
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S287TRNSLsPTIAPHPRD
T225RKRILtRQNSQ7tm_1PhosphoSitePlus
S285EKTRNsLSPTI7tm_1PhosphoSitePlus
T289NSLSPtIAPKLHPRD
S229LTRQNsQCNSV7tm_1PhosphoSitePlus
S257LKRYYsICQDTphosphoELM
S229LTRQNsQCNSVphosphoELM
S257LKRYYsICQDT7tm_1PhosphoSitePlus
S309GRLSTsLKLGP7tm_1PhosphoSitePlus
S285EKTRNsLSPTIHPRD
T289NSLSPtIAPKL7tm_1PhosphoSitePlus
S302EVRKLsNGRLSHPRD
S287TRNSLsPTIAP7tm_1PhosphoSitePlus
S233NSQCNsVRPGF7tm_1PhosphoSitePlus

Dephosphorylation site
DRD3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000373169R254HCOSMICCentral Nervous System Neoplasms18772396
ENSP00000373169R283WCOSMICPancreatic Cancer
ENSP00000373169A33DCOSMICOvarian Cancer21720365

Differential expressed protein
DRD3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DRD3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TY3H_HUMANDRD3_HUMANligand -> receptorHPMR
COMT_HUMANDRD3_HUMANligand -> receptorHPMR
DRD3_HUMANGNAI3_HUMANGPCR -> GproteingpDB
DRD3_HUMANGNAI1_HUMANGPCR -> GproteingpDB
DRD3_HUMANGNAI2_HUMANGPCR -> GproteingpDB
DRD3_HUMANGNAO_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04728Dopaminergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0002016regulation of blood volume by renin-angiotensinIEAbiological_process
GO:0007212dopamine receptor signaling pathwayIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0001591dopamine neurotransmitter receptor activity, couplISSmolecular_function
GO:0060134prepulse inhibitionIMPbiological_process
GO:0045840positive regulation of mitosisISSbiological_process
GO:0045776negative regulation of blood pressureIEAbiological_process
GO:0032922circadian regulation of gene expressionISSbiological_process
GO:0042493response to drugISSbiological_process
GO:0050709negative regulation of protein secretionIDAbiological_process
GO:0048715negative regulation of oligodendrocyte differentiaISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007195adenylate cyclase-inhibiting dopamine receptor sigIDAbiological_process
GO:0048148behavioral response to cocaineIEAbiological_process
GO:0051898negative regulation of protein kinase B signaling IEAbiological_process
GO:0035240dopamine bindingIEAmolecular_function
GO:0002031G-protein coupled receptor internalizationIDAbiological_process
GO:0014059regulation of dopamine secretionISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0050883musculoskeletal movement, spinal reflex actionIEAbiological_process
GO:0001591dopamine neurotransmitter receptor activity, couplIEAmolecular_function
GO:0060161positive regulation of dopamine receptor signalingISSbiological_process
GO:0040014regulation of multicellular organism growthIEAbiological_process
GO:0008542visual learningISSbiological_process
GO:0030139endocytic vesicleIEAcellular_component
GO:0005887integral to plasma membraneICcellular_component
GO:0050482arachidonic acid secretionIDAbiological_process
GO:0040012regulation of locomotionIEAbiological_process
GO:0032416negative regulation of sodium:hydrogen antiporter IEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0007612learningNASbiological_process
GO:0048148behavioral response to cocaineISSbiological_process
GO:0046717acid secretionIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0043278response to morphineISSbiological_process
GO:0045840positive regulation of mitosisIEAbiological_process
GO:0042220response to cocaineIEPbiological_process
GO:0008542visual learningIEAbiological_process
GO:0007194negative regulation of adenylate cyclase activityIDAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0019904protein domain specific bindingIEAmolecular_function
GO:0045177apical part of cellIEAcellular_component
GO:0030814regulation of cAMP metabolic processIDAbiological_process
GO:0050883musculoskeletal movement, spinal reflex actionISSbiological_process
GO:0034776response to histamineIDAbiological_process
GO:0008144drug bindingISSmolecular_function
GO:0045471response to ethanolIEAbiological_process
GO:0045187regulation of circadian sleep/wake cycle, sleepIEAbiological_process
GO:0006874cellular calcium ion homeostasisIDAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0007611learning or memoryNASbiological_process
GO:0019216regulation of lipid metabolic processIEAbiological_process
GO:0048715negative regulation of oligodendrocyte differentiaIEAbiological_process
GO:0045776negative regulation of blood pressureISSbiological_process
GO:0046717acid secretionISSbiological_process
GO:0060161positive regulation of dopamine receptor signalingIEAbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0030814regulation of cAMP metabolic processIEAbiological_process
GO:0032922circadian regulation of gene expressionIEAbiological_process
GO:0051584regulation of dopamine uptake involved in synapticICbiological_process
GO:0051898negative regulation of protein kinase B signaling ISSbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0060160negative regulation of dopamine receptor signalingIEAbiological_process
GO:0042417dopamine metabolic processICbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0007194negative regulation of adenylate cyclase activityIEAbiological_process
GO:0007191adenylate cyclase-activating dopamine receptor sigIDAbiological_process
GO:0004952dopamine neurotransmitter receptor activityIEAmolecular_function
GO:0001963synaptic transmission, dopaminergicIEAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0007626locomotory behaviorISSbiological_process
GO:0035815positive regulation of renal sodium excretionIEAbiological_process
GO:0002031G-protein coupled receptor internalizationIEAbiological_process
GO:0035176social behaviorNASbiological_process
GO:0043278response to morphineIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0014059regulation of dopamine secretionIEAbiological_process
GO:0042995cell projectionIEAcellular_component