Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TBB1_HUMAN
Description:tubulin, beta 1 class VI [Source:HGNC Symbol;Acc:16257]
Location:chr20 q13.32
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y55YYNEAyGRKYVTubulinPhosphoSitePlus
Y159KIREEyPDRIMTubulinPhosphoSitePlus
T439EDEEVtEEAEMPhosphoSitePlus; HPRD
Y208DNEALyDICFRTubulinPhosphoSitePlus
S278LTAQGsQQYRATubulin_CPhosphoSitePlus
Y222LTTPTyGDLNHTubulinPhosphoSitePlus

Dephosphorylation site
TBB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000217133S168CTCGAOvarian Cancer21720365, 18772890
ENSP00000217133S168CCOSMICOvarian Cancer21720365
ENSP00000217133M444ICOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000217133Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.6718973835
ENSP00000217133Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.7718973835
ENSP00000217133Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.6719714814

Hyperphosphorylation site
TBB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG8_HUMANTBB1_HUMANGprotein -> effectorgpDB
GNAS1_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBB3_HUMANTBB1_HUMANGprotein -> effectorgpDB
GNAQ_HUMANTBB1_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB1_HUMANGprotein -> effectorgpDB
GNAI3_HUMANTBB1_HUMANGprotein -> effectorgpDB
GNAI1_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBG13_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBG10_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBG5_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBG2_HUMANTBB1_HUMANGprotein -> effectorgpDB
GNAI2_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBG12_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBG1_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBB5_HUMANTBB1_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBG3_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBB1_HUMANTBB1_HUMANGprotein -> effectorgpDB
GBG11_HUMANTBB1_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
hsa04145Phagosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0044267cellular protein metabolic processTASbiological_process
GO:0007017microtubule-based processIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0051258protein polymerizationIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0006457protein foldingTASbiological_process
GO:0051225spindle assemblyIEAbiological_process
GO:0005874microtubuleIEAcellular_component
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0005525GTP bindingIEAmolecular_function
GO:0005200structural constituent of cytoskeletonIEAmolecular_function
GO:0006184GTP catabolic processIEAbiological_process
GO:0007018microtubule-based movementIEAbiological_process