| UniProt/SwissProt ID: | MTR1A_HUMAN |
| Description: | melatonin receptor 1A [Source:HGNC Symbol;Acc:7463] |
| Location: | chr4 q35.2 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| MTR1A_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| MTR1A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000302811 | F196L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000302811 | V327M | COSMIC | Central Nervous System Neoplasms | 21163964 |
| Differential expressed protein |
| MTR1A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MTR1A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SNAT_HUMAN | MTR1A_HUMAN | ligand -> receptor | HPMR |
| MTR1A_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| MTR1A_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| MTR1A_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| MTR1A_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| GLHA_HUMAN | MTR1A_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007623 | circadian rhythm | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | IDA | cellular_component |
| GO:0043235 | receptor complex | IDA | cellular_component |
| GO:0007617 | mating behavior | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0097159 | organic cyclic compound binding | IPI | molecular_function |
| GO:0042562 | hormone binding | IPI | molecular_function |
| GO:0008502 | melatonin receptor activity | IEA | molecular_function |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0030828 | positive regulation of cGMP biosynthetic process | IDA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |