Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FPR1_HUMAN
Description:formyl peptide receptor 1 [Source:HGNC Symbol;Acc:3826]
Location:chr19 q13.41
Node attribute:substrate; GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S328ALTEDsTQTSDBARK1(GRK2RegPhos
T339TATNStLPSAEBARK1(GRK2RegPhos
T331EDSTQtSDTATADRBK1HPRD
T329LTEDStQTSDTBARK1(GRK2RegPhos
T334TQTSDtATNSTBARK1(GRK2RegPhos
T329LTEDStQTSDTADRBK1HPRD
T329LTEDStQTSDTBARK1RegPhos
S338DTATNsTLPSAADRBK1HPRD
T336TSDTAtNSTLPGRK-2phosphoELM
S332DSTQTsDTATNGRK-2phosphoELM
T336TSDTAtNSTLPPhosphoSitePlus; RegPhos
S332DSTQTsDTATNPhosphoSitePlus; RegPhos
T334TQTSDtATNSTPhosphoSitePlus; RegPhos
S328ALTEDsTQTSDADRBK1HPRD
T329LTEDStQTSDTPhosphoSitePlus; RegPhos
T339TATNStLPSAEBARK1RegPhos
S211FIIGFsAPMSITM; 7tm_1PhosphoSitePlus
S332DSTQTsDTATNBARK1RegPhos
S328ALTEDsTQTSDBARK1RegPhos
T339TATNStLPSAEGRK-2phosphoELM
T331EDSTQtSDTATBARK1(GRK2RegPhos
S328ALTEDsTQTSDGRK-2phosphoELM
T331EDSTQtSDTATPhosphoSitePlus; RegPhos
T336TSDTAtNSTLPBARK1(GRK2RegPhos
S338DTATNsTLPSABARK1RegPhos
T334TQTSDtATNSTGRK-2phosphoELM
T339TATNStLPSAEADRBK1HPRD
S332DSTQTsDTATNBARK1(GRK2RegPhos
T331EDSTQtSDTATGRK-2phosphoELM
S220SIVAVsYGLIATM; 7tm_1PhosphoSitePlus
S215FSAPMsIVAVSTM; 7tm_1PhosphoSitePlus
S338DTATNsTLPSAGRK-2phosphoELM
T334TQTSDtATNSTADRBK1HPRD
T334TQTSDtATNSTBARK1RegPhos
T331EDSTQtSDTATBARK1RegPhos
T329LTEDStQTSDTGRK-2phosphoELM
T339TATNStLPSAEPhosphoSitePlus; RegPhos
S332DSTQTsDTATNADRBK1HPRD
T336TSDTAtNSTLPADRBK1HPRD
Y22AVSAGyLFLDILysis_SPhosphoSitePlus
T336TSDTAtNSTLPBARK1RegPhos
S338DTATNsTLPSABARK1(GRK2RegPhos
S338DTATNsTLPSAPhosphoSitePlus; RegPhos
S328ALTEDsTQTSDPhosphoSitePlus; RegPhos
S342NSTLPsAEVELPhosphoSitePlus

Dephosphorylation site
FPR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302707R123HBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000302707P187SCOSMICLung Cancer20668451
ENSP00000302707L272FCOSMICOvarian Cancer21720365

Differential expressed protein
FPR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FPR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANXA1_HUMANFPR1_HUMANligand -> receptorHPMR
FPR1_HUMANGNAI2_HUMANGPCR -> GproteingpDB
FPR1_HUMANGNAI1_HUMANGPCR -> GproteingpDB
FPR1_HUMANGNAI3_HUMANGPCR -> GproteingpDB
FPR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
FPR1_HUMANGNAZ_HUMANGPCR -> GproteingpDB
ZAGL2_HUMANFPR1_HUMANkinase -> substrateRegPhos
ARBK1_HUMANFPR1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
IP3KA_HUMANFPR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05150Staphylococcus aureus infection
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007263nitric oxide mediated signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0004982N-formyl peptide receptor activityIDAmolecular_function
GO:0005768endosomeTAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0006928cellular component movementTASbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recTASbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0006935chemotaxisIEAbiological_process
GO:0004872receptor activityTASmolecular_function


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