| UniProt/SwissProt ID: | GABR2_HUMAN |
| Description: | gamma-aminobutyric acid (GABA) B receptor, 2 [Source:HGNC Symbol;Acc:4507] |
| Location: | chr9 q22.33 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S884 | IEDINsPEHIQ | PhosphoSitePlus; phosphoELM | |
| S379 | ETLHAsSRHQR | ANF_receptor | PhosphoSitePlus |
| T202 | RVGTLtQDVQR | ANF_receptor | PhosphoSitePlus |
| T200 | WKRVGtLTQDV | ANF_receptor | PhosphoSitePlus |
| T813 | DLEEVtMQLQD | HPRD | |
| T819 | MQLQDtPEKTT | PhosphoSitePlus; HPRD; SysPTM | |
| S924 | VSPTAsPRHRH | PhosphoSitePlus | |
| Dephosphorylation site |
| GABR2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000259455 | M514I | COSMIC | Melanoma | 21499247 | ENSP00000259455 | E421K | COSMIC | Melanoma | 21499247 | ENSP00000259455 | R381W | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000259455 | I879T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000259455 | V182M | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| GABR2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GABR2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DCE1_HUMAN | GABR2_HUMAN | ligand -> receptor | HPMR |
| GABR2_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| GABR2_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| GABR2_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| GABR2_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05032 | Morphine addiction |
| hsa04727 | GABAergic synapse |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007214 | gamma-aminobutyric acid signaling pathway | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0004965 | G-protein coupled GABA receptor activity | IEA | molecular_function |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0045211 | postsynaptic membrane | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0007194 | negative regulation of adenylate cyclase activity | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |