Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RAC2_HUMAN
Description:ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [Source:HGNC Symbol;Acc:9802]
Location:chr22 q13.1
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T167QRGLKtVFDEARasPhosphoSitePlus
T108HHCPStPIILVRasPhosphoSitePlus
T161ECSALtQRGLKRasPhosphoSitePlus
Y32AFPGEyIPTVFRasPhosphoSitePlus
Y64AGQEDyDRLRPRasPhosphoSitePlus

Dephosphorylation site
RAC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000249071I21MCOSMICHead and Neck Cancer21798893
ENSP00000249071D47YCOSMICCentral Nervous System Neoplasms18772396
ENSP00000249071P106HCOSMICMelanoma21499247
ENSP00000249071P29LSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000249071Pancreatic CancerNormal vs. CancertissueUp3.516215274

Hyperphosphorylation site
RAC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAI1_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBG2_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBB2_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBG10_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBG3_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBG8_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBG12_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBG13_HUMANRAC2_HUMANGprotein -> effectorgpDB
GNAI3_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBG5_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBG11_HUMANRAC2_HUMANGprotein -> effectorgpDB
GNAI2_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBB1_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBG1_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBB3_HUMANRAC2_HUMANGprotein -> effectorgpDB
GBB5_HUMANRAC2_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05212Pancreatic cancer
hsa04664Fc epsilon RI signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05416Viral myocarditis
hsa04510Focal adhesion
hsa05200Pathways in cancer
hsa04670Leukocyte transendothelial migration
hsa04360Axon guidance
hsa04010MAPK signaling pathway
hsa04662B cell receptor signaling pathway
hsa04520Adherens junction
hsa05210Colorectal cancer
hsa04666Fc gamma R-mediated phagocytosis
hsa04310Wnt signaling pathway
hsa04370VEGF signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0010310regulation of hydrogen peroxide metabolic processTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0015031protein transportIEAbiological_process
GO:0006913nucleocytoplasmic transportIEAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0005635nuclear envelopeIEAcellular_component
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0016020membraneIEAcellular_component
GO:0030168platelet activationTASbiological_process
GO:0006184GTP catabolic processIEAbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0060263regulation of respiratory burstIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0006886intracellular protein transportIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0045453bone resorptionIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0006935chemotaxisIEAbiological_process
GO:0030031cell projection assemblyIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007411axon guidanceTASbiological_process


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