Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADCY6_HUMAN
Description:adenylate cyclase 6 [Source:HGNC Symbol;Acc:237]
Location:chr12 q13.12
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S54DAEPPsPTPAGPhosphoSitePlus; HPRD; phosphoELM
S607MGIDDsSKDNRDUF1053PhosphoSitePlus
T572AKLQRtRANSMPhosphoSitePlus
T40AGGFCtPRYMSPhosphoSitePlus
S576RTRANsMEGLMPhosphoSitePlus; HPRD; phosphoELM
S477RVGIHsGRVHCGuanylate_cycPhosphoSitePlus
S608GIDDSsKDNRGDUF1053PhosphoSitePlus

Dephosphorylation site
ADCY6_HUMAN do not have dephosphorylation site.

Mutation site
ADCY6_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000311405LeukemiaCancer vs. Cancer (chronic vs. acute leukemia)cell lineDown17449014

Hyperphosphorylation site
ADCY6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG12_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBG2_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBG8_HUMANADCY6_HUMANGprotein -> effectorgpDB
GNAI3_HUMANADCY6_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBG5_HUMANADCY6_HUMANGprotein -> effectorgpDB
GNAS1_HUMANADCY6_HUMANGprotein -> effectorgpDB
GNAI2_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBG13_HUMANADCY6_HUMANGprotein -> effectorgpDB
GNAO_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBG3_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBB1_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBB3_HUMANADCY6_HUMANGprotein -> effectorgpDB
GNAI1_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBG1_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBB5_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBG11_HUMANADCY6_HUMANGprotein -> effectorgpDB
GBG10_HUMANADCY6_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis
hsa04961Endocrine and other factor-regulated calcium reabs
hsa05166HTLV-I infection
hsa05032Morphine addiction
hsa04727GABAergic synapse
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05414Dilated cardiomyopathy
hsa04914Progesterone-mediated oocyte maturation
hsa04724Glutamatergic synapse
hsa00230Purine metabolism
hsa04270Vascular smooth muscle contraction
hsa04970Salivary secretion
hsa04742Taste transduction
hsa04976Bile secretion
hsa04962Vasopressin-regulated water reabsorption
hsa04540Gap junction
hsa04723Retrograde endocannabinoid signaling
hsa04912GnRH signaling pathway
hsa04062Chemokine signaling pathway
hsa04916Melanogenesis
hsa04725Cholinergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007212dopamine receptor signaling pathwayIDAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0019901protein kinase bindingISSmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0071870cellular response to catecholamine stimulusIDAbiological_process
GO:0005929ciliumIEAcellular_component
GO:0007193adenylate cyclase-inhibiting G-protein coupled recTASbiological_process
GO:0004016adenylate cyclase activityIDAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0006833water transportTASbiological_process
GO:0016020membraneISScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recTASbiological_process
GO:0071380cellular response to prostaglandin E stimulusIDAbiological_process
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0006171cAMP biosynthetic processIDAbiological_process


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