| UniProt/SwissProt ID: | ADCY6_HUMAN |
| Description: | adenylate cyclase 6 [Source:HGNC Symbol;Acc:237] |
| Location: | chr12 q13.12 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S54 | DAEPPsPTPAG | PhosphoSitePlus; HPRD; phosphoELM | |
| S607 | MGIDDsSKDNR | DUF1053 | PhosphoSitePlus |
| T572 | AKLQRtRANSM | PhosphoSitePlus | |
| T40 | AGGFCtPRYMS | PhosphoSitePlus | |
| S576 | RTRANsMEGLM | PhosphoSitePlus; HPRD; phosphoELM | |
| S477 | RVGIHsGRVHC | Guanylate_cyc | PhosphoSitePlus |
| S608 | GIDDSsKDNRG | DUF1053 | PhosphoSitePlus |
| Dephosphorylation site |
| ADCY6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ADCY6_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000311405 | Leukemia | Cancer vs. Cancer (chronic vs. acute leukemia) | cell line | Down | 17449014 | |
| Hyperphosphorylation site |
| ADCY6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG12_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GNAI3_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GNAS2_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GNAS1_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GNAI2_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GNAO_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GNAI1_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| GBG10_HUMAN | ADCY6_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04114 | Oocyte meiosis |
| hsa04961 | Endocrine and other factor-regulated calcium reabs |
| hsa05166 | HTLV-I infection |
| hsa05032 | Morphine addiction |
| hsa04727 | GABAergic synapse |
| hsa04971 | Gastric acid secretion |
| hsa04972 | Pancreatic secretion |
| hsa05414 | Dilated cardiomyopathy |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04724 | Glutamatergic synapse |
| hsa00230 | Purine metabolism |
| hsa04270 | Vascular smooth muscle contraction |
| hsa04970 | Salivary secretion |
| hsa04742 | Taste transduction |
| hsa04976 | Bile secretion |
| hsa04962 | Vasopressin-regulated water reabsorption |
| hsa04540 | Gap junction |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa04912 | GnRH signaling pathway |
| hsa04062 | Chemokine signaling pathway |
| hsa04916 | Melanogenesis |
| hsa04725 | Cholinergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007212 | dopamine receptor signaling pathway | IDA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0019901 | protein kinase binding | ISS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0071870 | cellular response to catecholamine stimulus | IDA | biological_process |
| GO:0005929 | cilium | IEA | cellular_component |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | TAS | biological_process |
| GO:0004016 | adenylate cyclase activity | IDA | molecular_function |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006833 | water transport | TAS | biological_process |
| GO:0016020 | membrane | ISS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0071377 | cellular response to glucagon stimulus | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007202 | activation of phospholipase C activity | TAS | biological_process |
| GO:0009190 | cyclic nucleotide biosynthetic process | IEA | biological_process |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | TAS | biological_process |
| GO:0071380 | cellular response to prostaglandin E stimulus | IDA | biological_process |
| GO:0034199 | activation of protein kinase A activity | TAS | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016849 | phosphorus-oxygen lyase activity | IEA | molecular_function |
| GO:0006171 | cAMP biosynthetic process | IDA | biological_process |