Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TBB5_HUMAN
Description:tubulin, beta class I [Source:HGNC Symbol;Acc:20778]
Location:chrHSCHR6_MHC_MANN p
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y340NKNSSyFVEWIRegPhos
Y59ATGGKyVPRAITubulinPhosphoSitePlus
T35IDPTGtYHGDSTubulinPhosphoSitePlus
S230LNHLVsATMSGPhosphoSitePlus
T107AKGHYtEGAELTubulinPhosphoSitePlus
S25FWEVIsDEHGIHPRD
Y51RISVYyNEATGHPRD
S48QLDRIsVYYNETubulinPhosphoSitePlus
T429QYQDAtAEEEEPhosphoSitePlus; HPRD
S278LTSRGsQQYRATubulin_CPhosphoSitePlus
S275FAPLTsRGSQQTubulin_CPhosphoSitePlus
S145GGGTGsGMGTLTubulinPhosphoSitePlus
S338VQNKNsSYFVETubulin_CPhosphoSitePlus
T199ENTDEtYCIDNTubulinPhosphoSitePlus
S115AELVDsVLDVVTubulinPhosphoSitePlus
Y36DPTGTyHGDSDHPRD; phosphoELM; RegPhos
S48QLDRIsVYYNEHPRD
S275FAPLTsRGSQQTTBK1HPRD; RegPhos
Y422DLVSEyQQYQDPhosphoSitePlus
Y51RISVYyNEATGTubulinPhosphoSitePlus
S172FSVVPsPKVSDTubulinPhosphoSitePlus
S339QNKNSsYFVEWTubulin_CPhosphoSitePlus
Y159KIREEyPDRIMTubulinPhosphoSitePlus
T274GFAPLtSRGSQTubulin_CPhosphoSitePlus
S138FQLTHsLGGGTTubulinPhosphoSitePlus
Y310PRHGRyLTVAATubulin_CPhosphoSitePlus
Y340NKNSSyFVEWITubulin_CPhosphoSitePlus
T149GSGMGtLLISKTubulinPhosphoSitePlus
T221KLTTPtYGDLNTubulinPhosphoSitePlus
Y50DRISVyYNEATHPRD
Y183TVVEPyNATLSTubulinPhosphoSitePlus
Y222LTTPTyGDLNHTubulinPhosphoSitePlus
Y208DNEALyDICFRTubulinPhosphoSitePlus
T55YYNEAtGGKYVHPRD
Y36DPTGTyHGDSDTubulinPhosphoSitePlus
T312HGRYLtVAAVFTubulin_CPhosphoSitePlus
Y425SEYQQyQDATAPhosphoSitePlus
T218RTLKLtTPTYGTubulinPhosphoSitePlus
S75PGTMDsVRSGPTubulinPhosphoSitePlus
S25FWEVIsDEHGITubulinPhosphoSitePlus
S78MDSVRsGPFGQTubulinPhosphoSitePlus
Y106WAKGHyTEGAETubulinPhosphoSitePlus
Y200NTDETyCIDNETubulinPhosphoSitePlus
Y281RGSQQyRALTVTubulin_CPhosphoSitePlus
T285QYRALtVPELTTubulin_CPhosphoSitePlus
S95FVFGQsGAGNNTubulinPhosphoSitePlus
S40TYHGDsDLQLDTubulinPhosphoSitePlus
T196QLVENtDETYCTubulinPhosphoSitePlus
S126RKEAEsCDCLQTubulinPhosphoSitePlus
T219TLKLTtPTYGDTubulinPhosphoSitePlus
S322FRGRMsMKEVDTubulin_CPhosphoSitePlus
S382LFKRIsEQFTATubulin_CPhosphoSitePlus
T55YYNEAtGGKYVTubulinPhosphoSitePlus
Y50DRISVyYNEATTubulinPhosphoSitePlus

Dephosphorylation site
TBB5_HUMAN do not have dephosphorylation site.

Mutation site
TBB5_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000406811LeukemiaNormal vs. Cancercell lineDown0.3917022645
ENSP00000406811LeukemiaNormal vs. Cancercell lineDown0.3517022645
ENSP00000406811Esophageal CancerNormal vs. CancertissueDown0.1719142970
ENSP00000406811MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.3417854218
ENSP00000406811MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) silenced)cell lineUp1.217854218
ENSP00000406811Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.218491314
ENSP00000406811Hepatocellular CarcinomaNormal vs. CancertissueUp2.111866469
ENSP00000406811hepatitis B virusNormal vs. CancertissueUp1.814654528
ENSP00000406811hepatitis C virusNormal vs. CancertissueUp5.114654528
ENSP00000406811hepatitis B virusNormal vs. CancertissueUp2.117671684
ENSP00000406811Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000406811Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp2.820804217
ENSP00000406811Gastric CancerMetastasiscell lineUp1.317022644
ENSP00000406811Breast CancerMetastasiscell lineUp1.318582095
ENSP00000406811Breast CancerNormal vs. CancertissueUp1.720087651
ENSP00000406811Oral CancerNormal vs. CancertissueUp5.719691830
ENSP00000406811acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp3.517655343
ENSP00000406811MelanomaTreatment (none vs. kojic acid treatment)cell lineDown118630942
ENSP00000406811Ovarian CancerNormal vs. Cancercell lineUp6.615591324
ENSP00000406811Gastric CancerNormal vs. CancertissueUp8.115761955
ENSP00000406811Hepatocellular CarcinomaNormal vs. CancertissueUp211866469
ENSP00000406811pancreatic ductal adenocarcinomaNormal vs. CancertissueUp17492507

Hyperphosphorylation site
TBB5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAS2_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBG2_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBG10_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBG8_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBG13_HUMANTBB5_HUMANGprotein -> effectorgpDB
GNAQ_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBG12_HUMANTBB5_HUMANGprotein -> effectorgpDB
GNAI2_HUMANTBB5_HUMANGprotein -> effectorgpDB
GNAI3_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBB5_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBG1_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBB3_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB5_HUMANGprotein -> effectorgpDB
GNAI1_HUMANTBB5_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBB1_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBG11_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBG3_HUMANTBB5_HUMANGprotein -> effectorgpDB
GBG5_HUMANTBB5_HUMANGprotein -> effectorgpDB
GNAS1_HUMANTBB5_HUMANGprotein -> effectorgpDB
ZAGL2_HUMANTBB5_HUMANkinase -> substrateRegPhos
TTBK1_HUMANTBB5_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05130Pathogenic Escherichia coli infection
hsa04540Gap junction
hsa04145Phagosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051258protein polymerizationIEAbiological_process
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0051301cell divisionTASbiological_process
GO:0051225spindle assemblyIEAbiological_process
GO:0007017microtubule-based processTASbiological_process
GO:0005198structural molecule activityTASmolecular_function
GO:0030705cytoskeleton-dependent intracellular transportTASbiological_process
GO:0005641nuclear envelope lumenIDAcellular_component
GO:0009987cellular processIDAbiological_process
GO:0007017microtubule-based processIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0003924GTPase activityIEAmolecular_function
GO:0006928cellular component movementTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0042267natural killer cell mediated cytotoxicityNASbiological_process
GO:0007018microtubule-based movementIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0032403protein complex bindingIEAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005856cytoskeletonTAScellular_component
GO:0042288MHC class I protein bindingIDAmolecular_function
GO:0006184GTP catabolic processIEAbiological_process
GO:0005874microtubuleIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005525GTP bindingIEAmolecular_function
GO:0044297cell bodyIDAcellular_component
GO:0005200structural constituent of cytoskeletonIEAmolecular_function