Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCR5_HUMAN
Description:chemokine (C-C motif) receptor 5 (gene/pseudogene) [Source:HGNC Symbol;Acc:1606]
Location:chr3 p21.31
Node attribute:substrate; GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S349GEQEIsVGRK_groupphosphoELM
S342SVYTRsTGEQEPhosphoSitePlus
S336APERAsSVYTRADRBK2HPRD
S337PERASsVYTRSPhosphoSitePlus
S349GEQEIsVGLGRK_groupRegPhos
S342SVYTRsTGEQEBARK2RegPhos
S342SVYTRsTGEQEGRK-3phosphoELM
S336APERAsSVYTRGRK_groupphosphoELM; RegPhos
Y339RASSVyTRSTGPhosphoSitePlus
S336APERAsSVYTRBARK2(GRK3RegPhos
S342SVYTRsTGEQEBARK2(GRK3RegPhos
S342SVYTRsTGEQEADRBK2HPRD
S349GEQEIsVGL__PhosphoSitePlus
S336APERAsSVYTRBARK2RegPhos
S349GEQEIsVADRBK2HPRD
S336APERAsSVYTRGRK-3phosphoELM
S349GEQEIsVGLBARK2RegPhos
S342SVYTRsTGEQEGRK_groupphosphoELM; RegPhos
S337PERASsVYTRSBARK2(GRK3RegPhos
S336APERAsSVYTRPhosphoSitePlus
S337PERASsVYTRSADRBK2HPRD
S337PERASsVYTRSGRK_groupphosphoELM; RegPhos
S337PERASsVYTRSGRK-3phosphoELM
S337PERASsVYTRSBARK2RegPhos

Dephosphorylation site
CCR5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000404881N306KCOSMICLung Cancer20668451
ENSP00000292303K191NCOSMICLung Cancer20668451
ENSP00000343985A331DCOSMICLung Cancer20668451
ENSP00000404881V134LCOSMICLung Cancer20668451
ENSP00000292303V134LCOSMICLung Cancer20668451
ENSP00000343985R341LCOSMICHead and Neck Cancer21798897
ENSP00000404881K191NCOSMICLung Cancer20668451
ENSP00000292303A331DCOSMICLung Cancer20668451
ENSP00000343985V134LCOSMICLung Cancer20668451
ENSP00000404881R341LCOSMICHead and Neck Cancer21798897
ENSP00000292303N306KCOSMICLung Cancer20668451
ENSP00000404881A331DCOSMICLung Cancer20668451
ENSP00000292303R341LCOSMICHead and Neck Cancer21798897
ENSP00000343985N306KCOSMICLung Cancer20668451
ENSP00000343985K191NCOSMICLung Cancer20668451

Differential expressed protein
CCR5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCR5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCL14_HUMANCCR5_HUMANligand -> receptorHPMR
CCL3_HUMANCCR5_HUMANligand -> receptorHPMR
CCL8_HUMANCCR5_HUMANligand -> receptorHPMR
CCL5_HUMANCCR5_HUMANligand -> receptorHPMR
CCL4_HUMANCCR5_HUMANligand -> receptorHPMR
CCR5_HUMANGNAI3_HUMANGPCR -> GproteingpDB
CCR5_HUMANGNAI1_HUMANGPCR -> GproteingpDB
CCR5_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR5_HUMANGNAI2_HUMANGPCR -> GproteingpDB
ARBK2_HUMANCCR5_HUMANkinase -> substrateRegPhos
CL3L1_HUMANCCR5_HUMANotherKEGG
CC4L_HUMANCCR5_HUMANotherKEGG
CCL5_HUMANCCR5_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa04062Chemokine signaling pathway
hsa05203Viral carcinogenesis
hsa04060Cytokine-cytokine receptor interaction
hsa05145Toxoplasmosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004435phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0006955immune responseTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process
GO:0071222cellular response to lipopolysaccharideIEPbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0000165MAPK cascadeIEPbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0016032viral reproductionTASbiological_process
GO:0003779actin bindingIDAmolecular_function
GO:0014808release of sequestered calcium ion into cytosol byIDAbiological_process
GO:0006816calcium ion transportIDAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0005768endosomeIDAcellular_component
GO:0006968cellular defense responseTASbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0071791chemokine (C-C motif) ligand 5 bindingIPImolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0006935chemotaxisTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0016493C-C chemokine receptor activityIDAmolecular_function
GO:0023052signalingIEPbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0030260entry into host cellTASbiological_process
GO:0019957C-C chemokine bindingIPImolecular_function
GO:0007267cell-cell signalingIDAbiological_process
GO:0015026coreceptor activityTASmolecular_function
GO:0002407dendritic cell chemotaxisTASbiological_process
GO:0004950chemokine receptor activityTASmolecular_function
GO:0070098chemokine-mediated signaling pathwayTASbiological_process
GO:0070723response to cholesterolIMPbiological_process
GO:0019722calcium-mediated signalingIDAbiological_process
GO:0009897external side of plasma membraneIDAcellular_component


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