Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GABR1_HUMAN
Description:gamma-aminobutyric acid (GABA) B receptor, 1 [Source:HGNC Symbol;Acc:4070]
Location:chrHSCHR6_MHC_APD p2
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S879MKTGSsTNNNEHPRD
T818KTGSStNNNEEHPRD
S816TMKTGsSTNNNHPRD
T930RRHPPtPPEPSPhosphoSitePlus
S762MKTGSsTNNNEHPRD
S761TMKTGsSTNNNHPRD
Y776GIFYGyKGLLL7tm_3; TMPhosphoSitePlus
T880KTGSStNNNEEHPRD
T759QDTMKtGSSTNHPRD
S878TMKTGsSTNNNHPRD
Y209DILPDyELKLIANF_receptorPhosphoSitePlus
T876QDTMKtGSSTNHPRD
T814QDTMKtGSSTNHPRD
S817MKTGSsTNNNEHPRD
T763KTGSStNNNEEHPRD

Dephosphorylation site
GABR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000419061R329*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000366211R212*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000348248R212*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000366176R329*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000366215R267*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000366233R329*BIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
GABR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GABR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DCE1_HUMANGABR1_HUMANligand -> receptorHPMR
GABR1_HUMANGNAI2_HUMANGPCR -> GproteingpDB
GABR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
GABR1_HUMANGNAI1_HUMANGPCR -> GproteingpDB
GABR1_HUMANGNAI3_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05032Morphine addiction
hsa04727GABAergic synapse
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0038037G-protein coupled receptor dimeric complexIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005576extracellular regionIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0007214gamma-aminobutyric acid signaling pathwayIEAbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0004965G-protein coupled GABA receptor activityIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0045211postsynaptic membraneIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0007268synaptic transmissionTASbiological_process
GO:0042734presynaptic membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007194negative regulation of adenylate cyclase activityTASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function


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