Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CXCR4_HUMAN
Description:chemokine (C-X-C motif) receptor 4 [Source:HGNC Symbol;Acc:2561]
Location:chr2 q22.1
Node attribute:PPI(target); GPCR; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T342HSSVStESESSPhosphoSitePlus
S325ALTSVsRGSSLHPRD
S338KRGGHsSVSTEPhosphoSitePlus; phosphoELM
S321ALTSVsRGSSLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S18TEEMGsGDYDSCXCR4_NPhosphoSitePlus
S323QHALTsVSRGSHPRD
S348ESESSsFHHPRD; phosphoELM; SysPTM
Y12YTSDNyTEEMGCXCR4_NPhosphoSitePlus
S352SSFHHPRD; phosphoELM; SysPTM
S347TESESsSFHSSPhosphoSitePlus
Y157AEKVVyVGVWITM; 7tm_1PhosphoSitePlus
T318AQHALtSVSRGPhosphoSitePlus; HPRD
S344SVSTEsESSSFPhosphoSitePlus
S355SSSFHHPRD
S351SSSFHsS____PhosphoSitePlus
S324SVSRGsSLKILPhosphoSitePlus; HPRD; phosphoELM
S346STESEsSSFHSPhosphoSitePlus; SysPTM
S330SLKILsKGKRGPhosphoSitePlus; phosphoELM
S352SSFHSs_____PhosphoSitePlus; SysPTM
S5YTSDHPRD
S351SSSFHHPRD; phosphoELM
S346STESEsSSFHHPRD; phosphoELM; SysPTM
S352ESESSsFHHPRD; SysPTM
S328SVSRGsSLKILHPRD
Y7SDNYHPRD
S18TEEMGsGDYDSHPRD
S329VSRGSsLKILSHPRD
S319QHALTsVSRGSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S325VSRGSsLKILSPhosphoSitePlus; HPRD; phosphoELM
S348ESESSsFHSS_PhosphoSitePlus; SysPTM
S339RGGHSsVSTESPhosphoSitePlus; phosphoELM
S350STESEsSSFHHPRD
S347TESESsSFHphosphoELM
S341GHSSVsTESESPhosphoSitePlus; phosphoELM
T322AQHALtSVSRGHPRD
S356SSFHHPRD

Dephosphorylation site
CXCR4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000386884P174TCOSMICIntestines Cancer
ENSP00000386884A99VCOSMICHead and Neck Cancer
ENSP00000386884R34HCOSMICLung Cancer20668451

Differential expressed protein
CXCR4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CXCR4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SDF1_HUMANCXCR4_HUMANligand -> receptorHPMR
CXCR4_HUMANGNAI1_HUMANGPCR -> GproteingpDB
CXCR4_HUMANGNAI2_HUMANGPCR -> GproteingpDB
CXCR4_HUMANGNAI3_HUMANGPCR -> GproteingpDB
CXCR4_HUMANGNAO_HUMANGPCR -> GproteingpDB
SDF1_HUMANCXCR4_HUMANotherKEGG
MYC_HUMANCXCR4_HUMANTF -> target geneTRANSFAC
USF2_HUMANCXCR4_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04670Leukocyte transendothelial migration
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04060Cytokine-cytokine receptor interaction
hsa04360Axon guidance
hsa04672Intestinal immune network for IgA production

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048714positive regulation of oligodendrocyte differentiaIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006954inflammatory responseTASbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0030260entry into host cellTASbiological_process
GO:0015026coreceptor activityTASmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0003779actin bindingIDAmolecular_function
GO:0004950chemokine receptor activityIEAmolecular_function
GO:0008045motor neuron axon guidanceIEAbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0043217myelin maintenanceISSbiological_process
GO:0001666response to hypoxiaIEPbiological_process
GO:0048714positive regulation of oligodendrocyte differentiaISSbiological_process
GO:0008354germ cell migrationIEAbiological_process
GO:0030426growth coneIEAcellular_component
GO:0030334regulation of cell migrationIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0019722calcium-mediated signalingIMPbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process
GO:0043130ubiquitin bindingIDAmolecular_function
GO:0001667ameboidal cell migrationIEAbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0016494C-X-C chemokine receptor activityNASmolecular_function
GO:0007420brain developmentIEAbiological_process
GO:0009615response to virusTASbiological_process
GO:0031252cell leading edgeIDAcellular_component
GO:0050920regulation of chemotaxisIMPbiological_process
GO:0002407dendritic cell chemotaxisTASbiological_process
GO:0048699generation of neuronsIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0032027myosin light chain bindingIDAmolecular_function
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016023cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0061351neural precursor cell proliferationIEAbiological_process
GO:0043217myelin maintenanceIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0001764neuron migrationIEAbiological_process
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007281germ cell developmentIEAbiological_process
GO:0006915apoptotic processTASbiological_process


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