Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:IRK3_HUMAN
Description:potassium inwardly-rectifying channel, subfamily J, member 3 [Source:HGNC Symbol;Acc:6264]
Location:chr2 q24.1
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S385KERHNsVECLDIRKPhosphoSitePlus
S62HGNLGsETSRYIRKPhosphoSitePlus
S69TSRYLsDLFTTHPRD
S369MLLMSsPLIAPIRKPhosphoSitePlus
T73LSDLFtTLVDLHPRD
S65LGSETsRYLSDIRKPhosphoSitePlus

Dephosphorylation site
IRK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000295101L163FCOSMICSkin Cancer21984974
ENSP00000295101G9ECOSMICSkin Cancer21984974
ENSP00000295101D70ECOSMICPancreatic Cancer
ENSP00000295101E250KCOSMICHead and Neck Cancer21798897
ENSP00000295101C123FCOSMICSkin Cancer21984974
ENSP00000295101L211RBIOMARTBreast Cancer21930507, 21930502
ENSP00000295101V297IBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
IRK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
IRK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAQ_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBB1_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBG11_HUMANIRK3_HUMANGprotein -> effectorgpDB
GNAI3_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBB3_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBG10_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBG2_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBG12_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBG1_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBG3_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBB5_HUMANIRK3_HUMANGprotein -> effectorgpDB
GNAI2_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBB2_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBG13_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBG5_HUMANIRK3_HUMANGprotein -> effectorgpDB
GBG8_HUMANIRK3_HUMANGprotein -> effectorgpDB
GNAI1_HUMANIRK3_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05032Morphine addiction
hsa04724Glutamatergic synapse
hsa04728Dopaminergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04726Serotonergic synapse
hsa04725Cholinergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0009986cell surfaceIEAcellular_component
GO:0005242inward rectifier potassium channel activityIDAmolecular_function
GO:0030315T-tubuleIEAcellular_component
GO:0015467G-protein activated inward rectifier potassium chaIEAmolecular_function
GO:0008076voltage-gated potassium channel complexTAScellular_component
GO:0006813potassium ion transportTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0051602response to electrical stimulusIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23