Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRM2_HUMAN
Description:glutamate receptor, metabotropic 2 [Source:HGNC Symbol;Acc:4594]
Location:chr3 p21.2
Node attribute:GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S246VGRAMsRAAFEANF_receptorPhosphoSitePlus
S501PASRCsEPCLQNCD3GPhosphoSitePlus
S111VRASLsRGADGANF_receptorPhosphoSitePlus
S109DFVRAsLSRGAANF_receptorPhosphoSitePlus
T457RYNIFtYLRAGANF_receptorPhosphoSitePlus

Dephosphorylation site
GRM2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378492T868KCOSMICHead and Neck Cancer21798893

Differential expressed protein
GRM2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRM2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GRM2_HUMANGNAI2_HUMANGPCR -> GproteingpDB
GRM2_HUMANGNAI1_HUMANGPCR -> GproteingpDB
GRM2_HUMANGNAI3_HUMANGPCR -> GproteingpDB
GRM2_HUMANGNAO_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04724Glutamatergic synapse
hsa04080Neuroactive ligand-receptor interaction
hsa05030Cocaine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042734presynaptic membraneIEAcellular_component
GO:0001641group II metabotropic glutamate receptor activityIEAmolecular_function
GO:0007194negative regulation of adenylate cyclase activityTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005246calcium channel regulator activityIEAmolecular_function
GO:0008066glutamate receptor activityTASmolecular_function
GO:0030424axonIEAcellular_component
GO:0007268synaptic transmissionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0014047glutamate secretionIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0043005neuron projectionIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005622intracellularIEAcellular_component


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