| UniProt/SwissProt ID: | ACM2_HUMAN |
| Description: | cholinergic receptor, muscarinic 2 [Source:HGNC Symbol;Acc:1951] |
| Location: | chr7 q33 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S290 | DSTSVsAVASN | 7tm_1 | PhosphoSitePlus |
| S286 | ESSNDsTSVSA | GRK_group | phosphoELM |
| T287 | SSNDStSVSAV | GRK_group | phosphoELM |
| S234 | DPVSPsLVQGR | 7tm_1 | PhosphoSitePlus |
| S290 | DSTSVsAVASN | GRK_group | phosphoELM |
| S282 | GEEKEsSNDST | 7tm_1 | PhosphoSitePlus |
| S311 | NTVSTsLGHSK | 7tm_1 | PhosphoSitePlus |
| S294 | VSAVAsNMRDD | GRK_group | phosphoELM |
| T271 | PRDPVtENCVQ | GRK_group | phosphoELM |
| S309 | DENTVsTSLGH | GRK_group | phosphoELM |
| T271 | PRDPVtENCVQ | 7tm_1 | PhosphoSitePlus |
| S286 | ESSNDsTSVSA | 7tm_1 | PhosphoSitePlus |
| T302 | RDDEItQDENT | GRK_group | phosphoELM |
| S250 | NNNMPsSDDGL | 7tm_1 | PhosphoSitePlus |
| T310 | ENTVStSLGHS | 7tm_1 | PhosphoSitePlus |
| S283 | EEKESsNDSTS | 7tm_1 | PhosphoSitePlus |
| T307 | TQDENtVSTSL | GRK_group | phosphoELM |
| S251 | NNMPSsDDGLE | 7tm_1 | PhosphoSitePlus |
| T307 | TQDENtVSTSL | 7tm_1 | PhosphoSitePlus |
| S232 | NQDPVsPSLVQ | 7tm_1 | PhosphoSitePlus |
| S288 | SNDSTsVSAVA | 7tm_1 | PhosphoSitePlus |
| S311 | NTVSTsLGHSK | GRK_group | phosphoELM |
| S309 | DENTVsTSLGH | 7tm_1 | PhosphoSitePlus |
| T423 | PNTVWtIGYWL | 7tm_1 | PhosphoSitePlus |
| T302 | RDDEItQDENT | 7tm_1 | PhosphoSitePlus |
| S282 | GEEKEsSNDST | GRK_group | phosphoELM |
| S294 | VSAVAsNMRDD | 7tm_1 | PhosphoSitePlus |
| S250 | NNNMPsSDDGL | GRK_group | phosphoELM |
| S283 | EEKESsNDSTS | GRK_group | phosphoELM |
| S232 | NQDPVsPSLVQ | GRK_group | phosphoELM |
| S251 | NNMPSsDDGLE | GRK_group | phosphoELM |
| T310 | ENTVStSLGHS | GRK_group | phosphoELM |
| Y177 | EDGECyIQFFS | 7tm_1 | PhosphoSitePlus |
| T287 | SSNDStSVSAV | 7tm_1 | PhosphoSitePlus |
| S288 | SNDSTsVSAVA | GRK_group | phosphoELM |
| S234 | DPVSPsLVQGR | GRK_group | phosphoELM |
| Dephosphorylation site |
| ACM2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000319984 | R52H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000319984 | T15R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000319984 | R387S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000415386 | R52H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384937 | R387S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384401 | I144V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000319984 | V95G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384401 | R387S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000415386 | V95G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384937 | R52H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000319984 | W155* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000319984 | R387S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000380733 | I144V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000384401 | V95G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000319984 | S11N | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000384401 | R52H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384937 | T15R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000380733 | T15R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000399745 | V95G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000415386 | R387S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384937 | V95G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000380733 | V95G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000380733 | R52H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000399745 | R52H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000384937 | I144V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000415386 | I144V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000399745 | R387S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000319984 | V95G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000399745 | T15R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000415386 | T15R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000319984 | T15R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000319984 | I144V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000319984 | P17L | COSMIC | Skin Cancer | 21984974 | ENSP00000384401 | T15R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000399745 | I144V | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000319984 | R52H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000380733 | R387S | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| ACM2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ACM2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLAT_HUMAN | ACM2_HUMAN | ligand -> receptor | HPMR |
| ACM2_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| ACM2_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| ACM2_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| ACM2_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04725 | Cholinergic synapse |
| hsa04020 | Calcium signaling pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009615 | response to virus | IEP | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0008016 | regulation of heart contraction | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0007207 | phospholipase C-activating G-protein coupled acety | TAS | biological_process |
| GO:0007213 | G-protein coupled acetylcholine receptor signaling | IEA | biological_process |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled rec | TAS | biological_process |
| GO:0030054 | cell junction | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0016907 | G-protein coupled acetylcholine receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0045211 | postsynaptic membrane | IEA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |