Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LPAR1_HUMAN
Description:lysophosphatidic acid receptor 1 [Source:HGNC Symbol;Acc:3166]
Location:chr9 q31.3
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S244MSRHSsGPRRN7tm_1PhosphoSitePlus
T236YVRQRtMRMSR7tm_1PhosphoSitePlus
S240RTMRMsRHSSG7tm_1PhosphoSitePlus
S243RMSRHsSGPRR7tm_1PhosphoSitePlus

Dephosphorylation site
LPAR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363552L326FCOSMICSkin Cancer21984974
ENSP00000363552Y75CCOSMICOvarian Cancer21720365

Differential expressed protein
LPAR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LPAR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LIPH_HUMANLPAR1_HUMANligand -> receptorHPMR
PPA6_HUMANLPAR1_HUMANligand -> receptorHPMR
LPAR1_HUMANGNAI1_HUMANGPCR -> GproteingpDB
LPAR1_HUMANGNA12_HUMANGPCR -> GproteingpDB
LPAR1_HUMANGNAI3_HUMANGPCR -> GproteingpDB
LPAR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
LPAR1_HUMANGNAQ_HUMANGPCR -> GproteingpDB
LPAR1_HUMANGNAI2_HUMANGPCR -> GproteingpDB
LPAR1_HUMANGNA13_HUMANGPCR -> GproteingpDB
LPAR1_HUMANGNA11_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043198dendritic shaftIEAcellular_component
GO:0035025positive regulation of Rho protein signal transducIEAbiological_process
GO:0071453cellular response to oxygen levelsIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0000187activation of MAPK activityIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0030139endocytic vesicleIDAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0042552myelinationIEAbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0010942positive regulation of cell deathIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0071673positive regulation of smooth muscle cell chemotaxIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0032060bleb assemblyIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0060999positive regulation of dendritic spine developmentIEAbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0022008neurogenesisIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0010977negative regulation of neuron projection developmeIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0051482elevation of cytosolic calcium ion concentration iIEAbiological_process
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0070915lysophosphatidic acid receptor activityIEAmolecular_function


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