Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TBB4B_HUMAN
Description:tubulin, beta 4B class IVb [Source:HGNC Symbol;Acc:20771]
Location:chr9 q34.3
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y208DNEALyDICFRTubulinPhosphoSitePlus
S339QNKNSsYFVEWTubulin_CPhosphoSitePlus
T55YYNEAtGGKYVHPRD
S115AELVDsVLDVVTubulinPhosphoSitePlus
S40TYHGDsDLQLETubulinPhosphoSitePlus
S230LNHLVsATMSGPhosphoSitePlus
S322FRGRMsMKEVDHPRD; phosphoELM
S145GGGTGsGMGTLTubulinPhosphoSitePlus
T366LKMSAtFIGNSTubulin_CPhosphoSitePlus
T221KLTTPtYGDLNTubulinPhosphoSitePlus
T35IDPTGtYHGDSTubulinPhosphoSitePlus
T312HGRYLtVAAVFTubulin_CPhosphoSitePlus
Y340NKNSSyFVEWIHPRD; phosphoELM
T149GSGMGtLLISKTubulinPhosphoSitePlus
Y281RGSQQyRALTVTubulin_CPhosphoSitePlus
S338VQNKNsSYFVETubulin_CPhosphoSitePlus
S275FAPLTsRGSQQTubulin_CPhosphoSitePlus
S138FQLTHsLGGGTTubulinPhosphoSitePlus
Y50ERINVyYNEATTubulinPhosphoSitePlus
Y200NTDETyCIDNETubulinPhosphoSitePlus
S339QNKNSsYFVEWHPRD
S322FRGRMsMKEVDTubulin_CPhosphoSitePlus
T55YYNEAtGGKYVTubulinPhosphoSitePlus
S172FSVVPsPKVSDHPRD; phosphoELM
Y422DLVSEyQQYQDPhosphoSitePlus
T199ENTDEtYCIDNTubulinPhosphoSitePlus
T219TLKLTtPTYGDTubulinPhosphoSitePlus
T218RTLKLtTPTYGTubulinPhosphoSitePlus
Y425SEYQQyQDATAPhosphoSitePlus
T274GFAPLtSRGSQTubulin_CPhosphoSitePlus
S78MDSVRsGPFGQTubulinPhosphoSitePlus
S382LFKRIsEQFTATubulin_CPhosphoSitePlus
S338VQNKNsSYFVEHPRD; phosphoELM
S275FAPLTsRGSQQHPRD
Y51RINVYyNEATGTubulinPhosphoSitePlus
Y59ATGGKyVPRAVTubulinPhosphoSitePlus
Y310PRHGRyLTVAATubulin_CPhosphoSitePlus
S278LTSRGsQQYRATubulin_CPhosphoSitePlus
S172FSVVPsPKVSDTubulinPhosphoSitePlus
T196QLVENtDETYCTubulinPhosphoSitePlus
S126RKEAEsCDCLQTubulinPhosphoSitePlus
Y159KIREEyPDRIMTubulinPhosphoSitePlus
Y340NKNSSyFVEWITubulin_CPhosphoSitePlus
Y183TVVEPyNATLSTubulinPhosphoSitePlus
Y222LTTPTyGDLNHTubulinPhosphoSitePlus
T107AKGHYtEGAELTubulinPhosphoSitePlus
S95FVFGQsGAGNNTubulinPhosphoSitePlus
Y36DPTGTyHGDSDTubulinPhosphoSitePlus
Y106WAKGHyTEGAETubulinPhosphoSitePlus

Dephosphorylation site
TBB4B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000341289T351SCOSMICOvarian Cancer21720365
ENSP00000341289L289VBIOMARTBreast Cancer21930507, 21930502
ENSP00000341289F408ICOSMICOvarian Cancer21720365
ENSP00000341289F408ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000341289Esophageal CancerNormal vs. CancertissueDown0.1919142970
ENSP00000341289Esophageal CancerNormal vs. CancertissueDown0.2619142970
ENSP00000341289MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.517854218
ENSP00000341289MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) silenced)cell lineUp1.217854218
ENSP00000341289Hepatocellular CarcinomaMetastasiscell lineDown17214954
ENSP00000341289Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp2.420804217
ENSP00000341289breast ductal carcinomaNormal vs. CancertissueUp34020534901
ENSP00000341289acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp417655343
ENSP00000341289Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
TBB4B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG10_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBG1_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GNAQ_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GNAI3_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBB1_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GNAS1_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBB5_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBG2_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBG12_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GNAI1_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBG5_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBG8_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBB3_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBG11_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GNAI2_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBG3_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GBG13_HUMANTBB4B_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05130Pathogenic Escherichia coli infection
hsa04145Phagosome
hsa04540Gap junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000278mitotic cell cycleTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0006928cellular component movementTASbiological_process
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0005198structural molecule activityIEAmolecular_function
GO:0051258protein polymerizationIEAbiological_process
GO:0006184GTP catabolic processIEAbiological_process
GO:0042267natural killer cell mediated cytotoxicityNASbiological_process
GO:0051082unfolded protein bindingNASmolecular_function
GO:0003924GTPase activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0042288MHC class I protein bindingTASmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005856cytoskeletonTAScellular_component
GO:0007018microtubule-based movementIEAbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0005874microtubuleIDAcellular_component
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0006457protein foldingTASbiological_process


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