| UniProt/SwissProt ID: | NPY5R_HUMAN |
| Description: | neuropeptide Y receptor Y5 [Source:HGNC Symbol;Acc:7958] |
| Location: | chr4 q32.2 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S262 | LTLHPsKKSGP | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| NPY5R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000339377 | C226S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339377 | H231D | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000423474 | C226S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339377 | R302G | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000339377 | Q305L | COSMIC | Lung Cancer | 20668451 | ENSP00000423917 | C226S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000339377 | R364G | COSMIC | Lung Cancer | 20668451 | ENSP00000339377 | K292Q | COSMIC | Melanoma | 21499247 | ENSP00000339377 | S363Y | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| NPY5R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NPY5R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NPY_HUMAN | NPY5R_HUMAN | ligand -> receptor | HPMR |
| PYY_HUMAN | NPY5R_HUMAN | ligand -> receptor | HPMR |
| NPY5R_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| NPY5R_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| NPY5R_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| NPY5R_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004983 | neuropeptide Y receptor activity | TAS | molecular_function |
| GO:0003214 | cardiac left ventricle morphogenesis | IMP | biological_process |
| GO:0001601 | peptide YY receptor activity | IEA | molecular_function |
| GO:0001602 | pancreatic polypeptide receptor activity | IEA | molecular_function |
| GO:0007268 | synaptic transmission | IEA | biological_process |
| GO:0004983 | neuropeptide Y receptor activity | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0032229 | negative regulation of synaptic transmission, GABA | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0042755 | eating behavior | IEA | biological_process |
| GO:0048661 | positive regulation of smooth muscle cell prolifer | IEA | biological_process |
| GO:0014050 | negative regulation of glutamate secretion | IEA | biological_process |
| GO:0003151 | outflow tract morphogenesis | IMP | biological_process |
| GO:0002675 | positive regulation of acute inflammatory response | IEA | biological_process |
| GO:0060112 | generation of ovulation cycle rhythm | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |