Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TBB3_HUMAN
Description:Tubulin beta-3 chain [Source:UniProtKB/Swiss-Prot;Acc:Q13509]
Location:chr16 q24.3
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T409DEMEFtEAESNBARK1(GRK2RegPhos
S338IQSKNsSYFVETubulin_CPhosphoSitePlus
S444DDEEEsEAQGPMAPK_groupRegPhos
S339QSKNSsYFVEWTubulin_CPhosphoSitePlus
Y425SEYQQyQDATAPhosphoSitePlus
S444DDEEEsEAQGGRK-2phosphoELM
S382LFKRIsEQFTATubulin_CPhosphoSitePlus
S364RGLKMsSTFIGTubulin_CPhosphoSitePlus
T149GSGMGtLLISKTubulinPhosphoSitePlus
T196QLVENtDETYCTubulinPhosphoSitePlus
T312HGRYLtVATVFHPRD
S322FRGRMsMKEVDTubulin_CPhosphoSitePlus
S278LTARGsQQYRATubulin_CPhosphoSitePlus
T312HGRYLtVATVFTubulin_CPhosphoSitePlus
S75PGTMDsVRSGATubulinPhosphoSitePlus
S172FSVVPsPKVSDTubulinPhosphoSitePlus
Y310PRHGRyLTVATHPRD
T107AKGHYtEGAELTubulinPhosphoSitePlus
Y200NTDETyCIDNETubulinPhosphoSitePlus
T409DEMEFtEAESNGRK-2phosphoELM
S115AELVDsVLDVVTubulinPhosphoSitePlus
S444DDEEEsEAQGPRegPhos
T199ENTDEtYCIDNTubulinPhosphoSitePlus
Y310PRHGRyLTVATTubulin_CPhosphoSitePlus
S420MNDLVsEYQQYGRK-2phosphoELM
S322FRGRMsMKEVDHPRD
S444DDEEEsEAQGPBARK1(GRK2RegPhos
S420MNDLVsEYQQYBARK1(GRK2RegPhos
T315YLTVAtVFRGRTubulin_CPhosphoSitePlus
Y106WAKGHyTEGAETubulinPhosphoSitePlus
Y437EEGEMyEDDEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y340SKNSSyFVEWITubulin_CPhosphoSitePlus
Y208DNEALyDICFRTubulinPhosphoSitePlus
S365GLKMSsTFIGNTubulin_CPhosphoSitePlus
Y422DLVSEyQQYQDPhosphoSitePlus
S444DDEEEsEAQGHPRD; phosphoELM

Dephosphorylation site
TBB3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000320295R213CCOSMICPancreatic Cancer
ENSP00000320295F85SCOSMICOvarian Cancer21720365
ENSP00000320295G71RCOSMICOvarian Cancer21720365
ENSP00000320295E205KCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000320295Gastric CancerMetastasiscell lineUp1.817022644
ENSP00000320295Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp2.720804217
ENSP00000320295Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp4.220804217
ENSP00000320295Gastric CancerMetastasiscell lineUp1.817022644
ENSP00000320295Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.5219329653

Hyperphosphorylation site
TBB3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG5_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBG11_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBG13_HUMANTBB3_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBB3_HUMANGprotein -> effectorgpDB
GNAQ_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBG2_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBB3_HUMANTBB3_HUMANGprotein -> effectorgpDB
GNAI1_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBG3_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBG1_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBB3_HUMANGprotein -> effectorgpDB
GNAS1_HUMANTBB3_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB3_HUMANGprotein -> effectorgpDB
GNAI2_HUMANTBB3_HUMANGprotein -> effectorgpDB
GNAI3_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBG10_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBG8_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBB5_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBB1_HUMANTBB3_HUMANGprotein -> effectorgpDB
GBG12_HUMANTBB3_HUMANGprotein -> effectorgpDB
ARBK1_HUMANTBB3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANTBB3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05130Pathogenic Escherichia coli infection
hsa04540Gap junction
hsa04145Phagosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030424axonIEAcellular_component
GO:0030182neuron differentiationIEAbiological_process
GO:0007067mitosisIEAbiological_process
GO:0007018microtubule-based movementIEAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0051258protein polymerizationIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0005198structural molecule activityIEAmolecular_function
GO:0015630microtubule cytoskeletonIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0006457protein foldingTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0007017microtubule-based processIEAbiological_process
GO:0006184GTP catabolic processIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0005874microtubuleIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0042277peptide bindingIEAmolecular_function
GO:0007411axon guidanceIEAbiological_process
GO:0044267cellular protein metabolic processTASbiological_process


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