Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCR1_HUMAN
Description:chemokine (C-C motif) receptor 1 [Source:HGNC Symbol;Acc:1602]
Location:chr3 p21.31
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S340RLERVsSTSPSPhosphoSitePlus
T342ERVSStSPSTGPhosphoSitePlus
S332WLPFLsVDRLEPhosphoSitePlus
S352GEHELsAHPRD
S345SSTSPsTGEHEPhosphoSitePlus
S352GEHELsAGF__PhosphoSitePlus
S343RVSSTsPSTGEPhosphoSitePlus
T346STSPStGEHELPhosphoSitePlus
S341LERVSsTSPSTPhosphoSitePlus
Y41LLPPLySLVFVTMPhosphoSitePlus

Dephosphorylation site
CCR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000296140T128MCOSMICPancreatic Cancer
ENSP00000296140L351FCOSMICMelanoma
ENSP00000296140M1ICOSMICMelanoma

Differential expressed protein
CCR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCL14_HUMANCCR1_HUMANligand -> receptorHPMR
CCL16_HUMANCCR1_HUMANligand -> receptorHPMR
CCL2_HUMANCCR1_HUMANligand -> receptorHPMR
CCL23_HUMANCCR1_HUMANligand -> receptorHPMR
CCL15_HUMANCCR1_HUMANligand -> receptorHPMR
CCL7_HUMANCCR1_HUMANligand -> receptorHPMR
CCL3_HUMANCCR1_HUMANligand -> receptorHPMR
CCR1_HUMANGNAI2_HUMANGPCR -> GproteingpDB
CCR1_HUMANGNAI1_HUMANGPCR -> GproteingpDB
CCR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR1_HUMANGNAI3_HUMANGPCR -> GproteingpDB
CCL14_HUMANCCR1_HUMANotherKEGG
CCL15_HUMANCCR1_HUMANotherKEGG
CCL7_HUMANCCR1_HUMANotherKEGG
CCL16_HUMANCCR1_HUMANotherKEGG
CCL23_HUMANCCR1_HUMANotherKEGG
CCL5_HUMANCCR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006955immune responseIDAbiological_process
GO:0006935chemotaxisNASbiological_process
GO:0019221cytokine-mediated signaling pathwayNASbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIDAbiological_process
GO:0071791chemokine (C-C motif) ligand 5 bindingIPImolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0016493C-C chemokine receptor activityIDAmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0019957C-C chemokine bindingIPImolecular_function
GO:0030502negative regulation of bone mineralizationIMPbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0007267cell-cell signalingIDAbiological_process
GO:0002407dendritic cell chemotaxisTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0070098chemokine-mediated signaling pathwayIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0009611response to woundingTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0006874cellular calcium ion homeostasisIDAbiological_process
GO:0004435phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0006816calcium ion transportIDAbiological_process
GO:0090026positive regulation of monocyte chemotaxisIDAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0045672positive regulation of osteoclast differentiationIMPbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0010629negative regulation of gene expressionIMPbiological_process
GO:0035717chemokine (C-C motif) ligand 7 bindingIPImolecular_function
GO:0006887exocytosisIDAbiological_process
GO:0051928positive regulation of calcium ion transportIDAbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupTASbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0004950chemokine receptor activityIDAmolecular_function


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