| UniProt/SwissProt ID: | LPAR3_HUMAN |
| Description: | lysophosphatidic acid receptor 3 [Source:HGNC Symbol;Acc:14298] |
| Location: | chr1 p22.3 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y206 | IMVVVyLRIYV | 7tm_1; TM | PhosphoSitePlus |
| Y301 | KDEDMyGTMKK | PhosphoSitePlus | |
| Y293 | VNPIIySYKDE | 7tm_1; TM | PhosphoSitePlus |
| S321 | PERRPsRIPST | PhosphoSitePlus | |
| Dephosphorylation site |
| LPAR3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000359643 | G302D | COSMIC | Lung Cancer | 20668451 | ENSP00000359643 | T90A | COSMIC | Lung Cancer | 20668451 | ENSP00000359643 | A175fs*61 | COSMIC | Ovarian Cancer | 21720365 | ENSP00000359643 | P320L | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| LPAR3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LPAR3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LPAR3_HUMAN | GNA12_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR3_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR3_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR3_HUMAN | GNA13_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR3_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR3_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR3_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR3_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0001965 | G-protein alpha-subunit binding | IEA | molecular_function |
| GO:0032060 | bleb assembly | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0043410 | positive regulation of MAPK cascade | IEA | biological_process |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0008289 | lipid binding | TAS | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0051928 | positive regulation of calcium ion transport | IEA | biological_process |
| GO:0070915 | lysophosphatidic acid receptor activity | IEA | molecular_function |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0051482 | elevation of cytosolic calcium ion concentration i | IEA | biological_process |
| GO:0000187 | activation of MAPK activity | IEA | biological_process |