Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TBA4A_HUMAN
Description:tubulin, alpha 4a [Source:HGNC Symbol;Acc:12407]
Location:chr2 q35
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T361NYQPPtVVPGGTubulin_CPhosphoSitePlus
Y161RLSVDyGKKSKTubulinPhosphoSitePlus
Y357KVGINyQPPTVHPRD; phosphoELM; RegPhos
Y432ALEKDyEEVGISYKHPRD; RegPhos
S6HVGQphosphoELM
T239IVSSItASLRFPhosphoSitePlus
S340IKTKRsIQFVDTubulin_CPhosphoSitePlus
S277YAPVIsAEKAYTubulin_CPhosphoSitePlus
Y319ACCLLyRGDVVRegPhos
S379AVCMLsNTTAITubulin_CPhosphoSitePlus
S237SQIVSsITASLPhosphoSitePlus
Y210DNEAIyDICRRTubulinPhosphoSitePlus
S6MRECIsVHVGQRegPhos
T193ILTTHtTLEHSTubulinPhosphoSitePlus
Y172LEFSIyPAPQVTubulinPhosphoSitePlus
S232LNRLIsQIVSSPhosphoSitePlus; HPRD
Y108YARGHyTIGKETubulinPhosphoSitePlus
Y432ALEKDyEEVGIPhosphoSitePlus
Y319ACCLLyRGDVVTubulin_CPhosphoSitePlus
Y440VGIDSyEDEDEPhosphoSitePlus; HPRD; phosphoELM
S439EVGIDsYEDEDPhosphoSitePlus; HPRD; phosphoELM
S158LMERLsVDYGKTubulinPhosphoSitePlus
S236ISQIVsSITASPhosphoSitePlus
S340IKTKRsIQFVDHPRD; phosphoELM
Y272FPLATyAPVISTubulin_CPhosphoSitePlus
T190YNSILtTHTTLTubulinPhosphoSitePlus
T225ERPTYtNLNRLTubulinPhosphoSitePlus
S287YHEQLsVAEITTubulin_CPhosphoSitePlus
T292SVAEItNACFETubulin_CPhosphoSitePlus
Y262TNLVPyPRIHFPhosphoSitePlus
T271HFPLAtYAPVIHPRD
T94PEQLItGKEDATubulinPhosphoSitePlus
Y185AVVEPyNSILTTubulinPhosphoSitePlus
Y357KVGINyQPPTVTubulin_CPhosphoSitePlus
Y224IERPTyTNLNRTubulinPhosphoSitePlus
S158LMERLsVDYGKHPRD
T73VDLEPtVIDEITubulinPhosphoSitePlus
S379AVCMLsNTTAIHPRD
Y272FPLATyAPVISHPRD; phosphoELM; RegPhos
Y161RLSVDyGKKSKHPRD; RegPhos
Y312PRHGKyMACCLTubulin_CPhosphoSitePlus
Y399KFDLMyAKRAFPhosphoSitePlus
T271HFPLAtYAPVITubulin_CPhosphoSitePlus
T223DIERPtYTNLNTubulinPhosphoSitePlus
S48GGGDDsFTTFFHPRD; RegPhos
S48GGGDDsFTTFFTubulinPhosphoSitePlus
Y282SAEKAyHEQLSTubulin_CPhosphoSitePlus
T194LTTHTtLEHSDTubulinPhosphoSitePlus
T50GDDSFtTFFCEHPRD
T191NSILTtHTTLETubulinPhosphoSitePlus
S187VEPYNsILTTHTubulinPhosphoSitePlus
Y408AFVHWyVGEGMPhosphoSitePlus
T109ARGHYtIGKEITubulinPhosphoSitePlus
S198TTLEHsDCAFMTubulinPhosphoSitePlus
S241SSITAsLRFDGPhosphoSitePlus
Y103DAANNyARGHYTubulinPhosphoSitePlus
T349VDWCPtGFKVGTubulin_CPhosphoSitePlus

Dephosphorylation site
TBA4A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000248437H88YCOSMICHead and Neck Cancer21984974
ENSP00000248437I5MBIOMARTBreast Cancer21930507, 21930502
ENSP00000248437D218HCOSMICOvarian Cancer21720365
ENSP00000248437R79QCOSMICOvarian Cancer21720365
ENSP00000248437Y161CCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000248437Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.718646787
ENSP00000248437Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.5119329653
ENSP00000248437Breast CancerNormal vs. CancertissueDown0.5720739354
ENSP00000248437Breast CancerNormal vs. CancertissueDown0.5720739354

Hyperphosphorylation site
TBA4A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG12_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GNAI2_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBG1_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBB3_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GNAS1_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBB1_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GNAI1_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBG11_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBG2_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBG8_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GNAQ_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBB5_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GNAI3_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBG3_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBG10_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBG13_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBG5_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA4A_HUMANGprotein -> effectorgpDB
ZAGL2_HUMANTBA4A_HUMANkinase -> substrateRegPhos
KSYK_HUMANTBA4A_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection
hsa04145Phagosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007018microtubule-based movementIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005576extracellular regionTAScellular_component
GO:0043234protein complexIEAcellular_component
GO:0005198structural molecule activityIEAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0051258protein polymerizationIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0006184GTP catabolic processIEAbiological_process
GO:0006457protein foldingTASbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0005874microtubuleIEAcellular_component
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0003924GTPase activityIEAmolecular_function
GO:0005881cytoplasmic microtubuleIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005200structural constituent of cytoskeletonIEAmolecular_function
GO:0044267cellular protein metabolic processTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process


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