Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TBA1B_HUMAN
Description:tubulin, alpha 1b [Source:HGNC Symbol;Acc:18809]
Location:chr12 q13.12
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y357KVGINyQPPTVTubulin_CPhosphoSitePlus
T56TFFSEtGAGKHTubulinPhosphoSitePlus
Y224IERPTyTNLNRTubulinPhosphoSitePlus
S198TTLEHsDCAFMTubulinPhosphoSitePlus
Y103DAANNyARGHYTubulinPhosphoSitePlus
T41MPSDKtIGGGDTubulinPhosphoSitePlus
S236ISQIVsSITASPhosphoSitePlus
T225ERPTYtNLNRLTubulinPhosphoSitePlus
Y210DNEAIyDICRRTubulinPhosphoSitePlus
T193ILTTHtTLEHSTubulinPhosphoSitePlus
Y83VRTGTyRQLFHTubulinPhosphoSitePlus
T190YNSILtTHTTLTubulinPhosphoSitePlus
T292SVAEItNACFETubulin_CPhosphoSitePlus
S187VEPYNsILTTHTubulinPhosphoSitePlus
T80IDEVRtGTYRQTubulinPhosphoSitePlus
T82EVRTGtYRQLFTubulinPhosphoSitePlus
T337IATIKtKRSIQTubulin_CPhosphoSitePlus
T41MPSDKtIGGGDHPRD
Y185AVVEPyNSILTTubulinPhosphoSitePlus
S48GGGDDsFNTFFHPRD; phosphoELM
T239IVSSItASLRFPhosphoSitePlus
Y399KFDLMyAKRAFPhosphoSitePlus
T194LTTHTtLEHSDTubulinPhosphoSitePlus
S54FNTFFsETGAGHPRD
Y312PRHGKyMACCLTubulin_CPhosphoSitePlus
Y108YARGHyTIGKETubulinPhosphoSitePlus
Y172LEFSIyPAPQVTubulinPhosphoSitePlus
S237SQIVSsITASLPhosphoSitePlus
Y432ALEKDyEEVGVPhosphoSitePlus
S151GSGFTsLLMERTubulinPhosphoSitePlus
Y161RLSVDyGKKSKTubulinPhosphoSitePlus
S287YHEQLsVAEITTubulin_CPhosphoSitePlus
T191NSILTtHTTLETubulinPhosphoSitePlus
Y262TNLVPyPRIHFPhosphoSitePlus
S340IKTKRsIQFVDTubulin_CPhosphoSitePlus; SysPTM
S48GGGDDsFNTFFTubulinPhosphoSitePlus
S232LNRLIsQIVSSPhosphoSitePlus; HPRD
T223DIERPtYTNLNTubulinPhosphoSitePlus
T361NYQPPtVVPGGTubulin_CPhosphoSitePlus
T334NAAIAtIKTKRTubulin_CPhosphoSitePlus
S158LMERLsVDYGKTubulinPhosphoSitePlus
Y408AFVHWyVGEGMPhosphoSitePlus
Y24ACWELyCLEHGTubulinPhosphoSitePlus
Y451EEGEEy_____PhosphoSitePlus
T51DDSFNtFFSETTubulinPhosphoSitePlus
T73VDLEPtVIDEVTubulinPhosphoSitePlus
T109ARGHYtIGKEITubulinPhosphoSitePlus
T349VDWCPtGFKVGTubulin_CPhosphoSitePlus
S439EVGVDsVEGEGPhosphoSitePlus; HPRD; phosphoELM
T94PEQLItGKEDATubulinPhosphoSitePlus
T51DDSFNtFFSETHPRD
T334NAAIAtIKTKRHPRD
Y319ACCLLyRGDVVTubulin_CPhosphoSitePlus
Y272FPLATyAPVISTubulin_CPhosphoSitePlus
S277YAPVIsAEKAYTubulin_CPhosphoSitePlus
Y282SAEKAyHEQLSTubulin_CPhosphoSitePlus
S340IKTKRsIQFVDHPRD; SysPTM
S379AVCMLsNTTAITubulin_CPhosphoSitePlus
S54FNTFFsETGAGTubulinPhosphoSitePlus
T271HFPLAtYAPVITubulin_CPhosphoSitePlus
S241SSITAsLRFDGPhosphoSitePlus

Dephosphorylation site
TBA1B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000336799E443QBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000336799Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp2.320804217
ENSP00000336799Oral CancerNormal vs. CancertissueUp3.919691830
ENSP00000336799acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343
ENSP00000336799Gastric CancerNormal vs. CancertissueDown0.4315761955

Hyperphosphorylation site
TBA1B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAO_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBG1_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBG5_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBG12_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBB3_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GNAS2_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBB2_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBB5_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GNAI1_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBG3_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBG13_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GNAQ_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBG2_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBG11_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBB1_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GNAS1_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GNAI2_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBG8_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GBG10_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GNAI3_HUMANTBA1B_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04145Phagosome
hsa04540Gap junction
hsa05130Pathogenic Escherichia coli infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005200structural constituent of cytoskeletonIEAmolecular_function
GO:0005874microtubuleIEAcellular_component
GO:0003924GTPase activityIEAmolecular_function
GO:0044267cellular protein metabolic processTASbiological_process
GO:0005874microtubuleTAScellular_component
GO:0005198structural molecule activityTASmolecular_function
GO:0030705cytoskeleton-dependent intracellular transportTASbiological_process
GO:0051301cell divisionTASbiological_process
GO:0007017microtubule-based processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043234protein complexIEAcellular_component
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0006457protein foldingTASbiological_process
GO:0005881cytoplasmic microtubuleIEAcellular_component
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0006184GTP catabolic processIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0051258protein polymerizationIEAbiological_process
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0007018microtubule-based movementIEAbiological_process


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