| UniProt/SwissProt ID: | ADCY5_HUMAN |
| Description: | adenylate cyclase 5 [Source:HGNC Symbol;Acc:236] |
| Location: | chr3 q21.1 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T368 | AIALRtNAQDQ | PhosphoSitePlus; HPRD | |
| S1138 | SGLNDsTYDKV | Guanylate_cyc | PhosphoSitePlus |
| T1146 | DKVGKtHIKAL | Guanylate_cyc | PhosphoSitePlus |
| Y1164 | MDQMKyINEHS | Guanylate_cyc | PhosphoSitePlus |
| Y1252 | GEMMTyFLNGG | Guanylate_cyc | PhosphoSitePlus |
| S1207 | TVNVAsRMDST | Guanylate_cyc | PhosphoSitePlus |
| S567 | RVGIHsGRVHC | Guanylate_cyc | PhosphoSitePlus |
| S1169 | YINEHsFNNFQ | Guanylate_cyc | PhosphoSitePlus |
| Dephosphorylation site |
| ADCY5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000419361 | V988A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000419361 | L986S | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ADCY5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ADCY5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG5_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GNAO_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GNAS2_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GNAS1_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GNAI1_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GNAI3_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBG10_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GNAI2_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBG12_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | ADCY5_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04540 | Gap junction |
| hsa04972 | Pancreatic secretion |
| hsa04976 | Bile secretion |
| hsa04727 | GABAergic synapse |
| hsa04916 | Melanogenesis |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04062 | Chemokine signaling pathway |
| hsa05414 | Dilated cardiomyopathy |
| hsa04971 | Gastric acid secretion |
| hsa00230 | Purine metabolism |
| hsa04912 | GnRH signaling pathway |
| hsa05166 | HTLV-I infection |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa05031 | Amphetamine addiction |
| hsa04725 | Cholinergic synapse |
| hsa04728 | Dopaminergic synapse |
| hsa05030 | Cocaine addiction |
| hsa04270 | Vascular smooth muscle contraction |
| hsa04114 | Oocyte meiosis |
| hsa05034 | Alcoholism |
| hsa04726 | Serotonergic synapse |
| hsa04724 | Glutamatergic synapse |
| hsa05032 | Morphine addiction |
| hsa04970 | Salivary secretion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050885 | neuromuscular process controlling balance | IEA | biological_process |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0008179 | adenylate cyclase binding | IEA | molecular_function |
| GO:0007202 | activation of phospholipase C activity | TAS | biological_process |
| GO:0001973 | adenosine receptor signaling pathway | IEA | biological_process |
| GO:0071377 | cellular response to glucagon stimulus | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0007195 | adenylate cyclase-inhibiting dopamine receptor sig | IEA | biological_process |
| GO:0004016 | adenylate cyclase activity | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0007626 | locomotory behavior | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006833 | water transport | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | TAS | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | IEA | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0072372 | primary cilium | IEA | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0016849 | phosphorus-oxygen lyase activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | TAS | biological_process |
| GO:0009190 | cyclic nucleotide biosynthetic process | IEA | biological_process |
| GO:0007191 | adenylate cyclase-activating dopamine receptor sig | IEA | biological_process |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0034199 | activation of protein kinase A activity | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |