Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADCY5_HUMAN
Description:adenylate cyclase 5 [Source:HGNC Symbol;Acc:236]
Location:chr3 q21.1
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T368AIALRtNAQDQPhosphoSitePlus; HPRD
S1138SGLNDsTYDKVGuanylate_cycPhosphoSitePlus
T1146DKVGKtHIKALGuanylate_cycPhosphoSitePlus
Y1164MDQMKyINEHSGuanylate_cycPhosphoSitePlus
Y1252GEMMTyFLNGGGuanylate_cycPhosphoSitePlus
S1207TVNVAsRMDSTGuanylate_cycPhosphoSitePlus
S567RVGIHsGRVHCGuanylate_cycPhosphoSitePlus
S1169YINEHsFNNFQGuanylate_cycPhosphoSitePlus

Dephosphorylation site
ADCY5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000419361V988ABIOMARTBreast Cancer21930507, 21930502
ENSP00000419361L986SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ADCY5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADCY5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GBG5_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBG3_HUMANADCY5_HUMANGprotein -> effectorgpDB
GNAO_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBB1_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBB3_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBG1_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBG13_HUMANADCY5_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY5_HUMANGprotein -> effectorgpDB
GNAS1_HUMANADCY5_HUMANGprotein -> effectorgpDB
GNAI1_HUMANADCY5_HUMANGprotein -> effectorgpDB
GNAI3_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBG2_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBB5_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBB2_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBG11_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBG10_HUMANADCY5_HUMANGprotein -> effectorgpDB
GNAI2_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBG12_HUMANADCY5_HUMANGprotein -> effectorgpDB
GBG8_HUMANADCY5_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa04727GABAergic synapse
hsa04916Melanogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04062Chemokine signaling pathway
hsa05414Dilated cardiomyopathy
hsa04971Gastric acid secretion
hsa00230Purine metabolism
hsa04912GnRH signaling pathway
hsa05166HTLV-I infection
hsa04723Retrograde endocannabinoid signaling
hsa05031Amphetamine addiction
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa05030Cocaine addiction
hsa04270Vascular smooth muscle contraction
hsa04114Oocyte meiosis
hsa05034Alcoholism
hsa04726Serotonergic synapse
hsa04724Glutamatergic synapse
hsa05032Morphine addiction
hsa04970Salivary secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050885neuromuscular process controlling balanceIEAbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0008179adenylate cyclase bindingIEAmolecular_function
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0001973adenosine receptor signaling pathwayIEAbiological_process
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007195adenylate cyclase-inhibiting dopamine receptor sigIEAbiological_process
GO:0004016adenylate cyclase activityIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0007626locomotory behaviorIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0006833water transportTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0007189adenylate cyclase-activating G-protein coupled recTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recIEAbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0072372primary ciliumIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0007193adenylate cyclase-inhibiting G-protein coupled recTASbiological_process
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0007191adenylate cyclase-activating dopamine receptor sigIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007268synaptic transmissionTASbiological_process


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