Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AA1R_HUMAN
Description:adenosine A1 receptor [Source:HGNC Symbol;Acc:262]
Location:chr1 q32.1
Node attribute:GPCR; PPI(target)

Phosphorylation site
AA1R_HUMAN do not have phosphorylation site.

Dephosphorylation site
AA1R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000308549P285LCOSMICSkin Cancer21984974
ENSP00000308549E170KHPIColorectal Cancer16959974
ENSP00000338435E170KSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000356205E170KSjoblom2006Intestines Cancer16959974
ENSP00000308549E170KSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000338435E170KBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000356205E170KHPIColorectal Cancer16959974

Differential expressed protein
AA1R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AA1R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AA1R_HUMANGNAI1_HUMANGPCR -> GproteingpDB
AA1R_HUMANGNAI3_HUMANGPCR -> GproteingpDB
AA1R_HUMANGNAO_HUMANGPCR -> GproteingpDB
AA1R_HUMANGNAI2_HUMANGPCR -> GproteingpDB
GLHA_HUMANAA1R_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa05032Morphine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050890cognitionIEAbiological_process
GO:0032900negative regulation of neurotrophin productionIEAbiological_process
GO:0042323negative regulation of circadian sleep/wake cycle,IEAbiological_process
GO:0060079regulation of excitatory postsynaptic membrane potIEAbiological_process
GO:0097190apoptotic signaling pathwayTASbiological_process
GO:0035814negative regulation of renal sodium excretionIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0044297cell bodyIEAcellular_component
GO:0001883purine nucleoside bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0045777positive regulation of blood pressureIEAbiological_process
GO:0030673axolemmaIEAcellular_component
GO:0014050negative regulation of glutamate secretionIEAbiological_process
GO:0002686negative regulation of leukocyte migrationIEAbiological_process
GO:0042734presynaptic membraneIEAcellular_component
GO:0006612protein targeting to membraneIEAbiological_process
GO:0045822negative regulation of heart contractionIEAbiological_process
GO:0000186activation of MAPKK activityIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0046888negative regulation of hormone secretionIEAbiological_process
GO:0002793positive regulation of peptide secretionIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0048786presynaptic active zoneIEAcellular_component
GO:0043268positive regulation of potassium ion transportIEAbiological_process
GO:0031683G-protein beta/gamma-subunit complex bindingIEAmolecular_function
GO:0045908negative regulation of vasodilationIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0045741positive regulation of epidermal growth factor-actIEAbiological_process
GO:0045776negative regulation of blood pressureIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0003093regulation of glomerular filtrationIEAbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0001666response to hypoxiaIEAbiological_process
GO:0032795heterotrimeric G-protein bindingIEAmolecular_function
GO:0050965detection of temperature stimulus involved in sensIEAbiological_process
GO:0032229negative regulation of synaptic transmission, GABAIEAbiological_process
GO:0043195terminal buttonIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0004629phospholipase C activityIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0001609G-protein coupled adenosine receptor activityIEAmolecular_function
GO:0032279asymmetric synapseIEAcellular_component
GO:0055118negative regulation of cardiac muscle contractionIEAbiological_process
GO:0002087regulation of respiratory gaseous exchange by neurIEAbiological_process
GO:0006909phagocytosisTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0060087relaxation of vascular smooth muscleIEAbiological_process
GO:0050995negative regulation of lipid catabolic processIEAbiological_process
GO:0045211postsynaptic membraneIEAcellular_component
GO:0016042lipid catabolic processIEAbiological_process
GO:0070256negative regulation of mucus secretionIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007267cell-cell signalingTASbiological_process
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0001664G-protein coupled receptor bindingIEAmolecular_function
GO:0012505endomembrane systemIEAcellular_component
GO:0032244positive regulation of nucleoside transportIEAbiological_process
GO:0051967negative regulation of synaptic transmission, glutIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0001659temperature homeostasisIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0007193adenylate cyclase-inhibiting G-protein coupled recIEAbiological_process
GO:0035307positive regulation of protein dephosphorylationIEAbiological_process
GO:0002674negative regulation of acute inflammatory responseIEAbiological_process
GO:0055117regulation of cardiac muscle contractionIEAbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process