| UniProt/SwissProt ID: | RL3R2_HUMAN |
| Description: | relaxin/insulin-like family peptide receptor 4 [Source:HGNC Symbol;Acc:14666] |
| Location: | chr1 q22 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S362 | RESRPsTLLTN | PhosphoSitePlus | |
| T119 | CKMVLtATVLN | 7tm_1; TM | PhosphoSitePlus |
| Y126 | TVLNVyASIFL | 7tm_1; TM | PhosphoSitePlus |
| T78 | GPPSDtFVFNL | 7tm_1 | PhosphoSitePlus |
| T133 | SIFLItALSVA | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| RL3R2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000357301 | A84T | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000357301 | Lung Cancer | Normal vs. Cancer | tissue | Down | 0.29 | 17705522 |
| Hyperphosphorylation site |
| RL3R2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| INSL5_HUMAN | RL3R2_HUMAN | ligand -> receptor | HPMR |
| REL3_HUMAN | RL3R2_HUMAN | ligand -> receptor | HPMR |
| RL3R2_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| RL3R2_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| RL3R2_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| RL3R2_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| RL3R2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004945 | angiotensin type II receptor activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |