| UniProt/SwissProt ID: | C3AR_HUMAN |
| Description: | complement component 3a receptor 1 [Source:HGNC Symbol;Acc:1319] |
| Location: | chr12 p13.31 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S465 | EELTRsTHCPS | PhosphoSitePlus | |
| S470 | STHCPsNNVIS | PhosphoSitePlus | |
| T466 | ELTRStHCPSN | PhosphoSitePlus | |
| T463 | FSEELtRSTHC | PhosphoSitePlus | |
| S459 | LEAAFsEELTR | PhosphoSitePlus | |
| Dephosphorylation site |
| C3AR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| C3AR_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000302079 | acute lymphocytic leukemia | Normal vs. Cancer | tissue | Up | 19291297 | |
| Hyperphosphorylation site |
| C3AR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CO3_HUMAN | C3AR_HUMAN | ligand -> receptor | HPMR |
| C3AR_HUMAN | GNA12_HUMAN | GPCR -> Gprotein | gpDB |
| C3AR_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| C3AR_HUMAN | GNA13_HUMAN | GPCR -> Gprotein | gpDB |
| C3AR_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| C3AR_HUMAN | GNAZ_HUMAN | GPCR -> Gprotein | gpDB |
| C3AR_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| C3AR_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| IP3KA_HUMAN | C3AR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05150 | Staphylococcus aureus infection |
| hsa04610 | Complement and coagulation cascades |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0010575 | positive regulation vascular endothelial growth fa | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IGI | molecular_function |
| GO:0004943 | C3a anaphylatoxin receptor activity | IEA | molecular_function |
| GO:0006935 | chemotaxis | IEA | biological_process |
| GO:0008015 | blood circulation | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0045766 | positive regulation of angiogenesis | IEA | biological_process |
| GO:0006954 | inflammatory response | TAS | biological_process |
| GO:0090023 | positive regulation of neutrophil chemotaxis | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007204 | elevation of cytosolic calcium ion concentration | IGI | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004876 | complement component C3a receptor activity | TAS | molecular_function |
| GO:0004435 | phosphatidylinositol phospholipase C activity | TAS | molecular_function |
| GO:0010759 | positive regulation of macrophage chemotaxis | IEA | biological_process |