Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DRD2_HUMAN
Description:dopamine receptor D2 [Source:HGNC Symbol;Acc:3023]
Location:chr11 q23.2
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S229NTKRSsRAFRA7tm_1; Rifin_STEVORPhosphoSitePlus
T225RKRVNtKRSSR7tm_1; Rifin_STEVORPhosphoSitePlus
T144PMLYNtRYSSK7tm_1PhosphoSitePlus
T134SIDRYtAVAMP7tm_1PhosphoSitePlus
S354GKTRTsLKTMS7tm_1PhosphoSitePlus
S359SLKTMsRRKLS7tm_1PhosphoSitePlus
S228VNTKRsSRAFR7tm_1; Rifin_STEVORPhosphoSitePlus
S148NTRYSsKRRVT7tm_1PhosphoSitePlus
S147YNTRYsSKRRV7tm_1PhosphoSitePlus

Dephosphorylation site
DRD2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354859P32TCOSMICHead and Neck Cancer21798893
ENSP00000354859P347LCOSMICMelanoma21499247

Differential expressed protein
DRD2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DRD2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TY3H_HUMANDRD2_HUMANligand -> receptorHPMR
DRD2_HUMANGNAI1_HUMANGPCR -> GproteingpDB
DRD2_HUMANGNAO_HUMANGPCR -> GproteingpDB
DRD2_HUMANGNAI3_HUMANGPCR -> GproteingpDB
DRD2_HUMANGNAI2_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
hsa04728Dopaminergic synapse
hsa05034Alcoholism
hsa05030Cocaine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046488phosphatidylinositol metabolic processIEAbiological_process
GO:0007212dopamine receptor signaling pathwayIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0014059regulation of dopamine secretionIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0007194negative regulation of adenylate cyclase activityIEAbiological_process
GO:0009636response to toxinIEAbiological_process
GO:0060158phospholipase C-activating dopamine receptor signaIEAbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0048678response to axon injuryIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0008104protein localizationIEAbiological_process
GO:0051967negative regulation of synaptic transmission, glutIEAbiological_process
GO:0002028regulation of sodium ion transportIEAbiological_process
GO:0001976neurological system process involved in regulationIEAbiological_process
GO:0001964startle responseIEAbiological_process
GO:0009416response to light stimulusISSbiological_process
GO:0001963synaptic transmission, dopaminergicIEAbiological_process
GO:0007608sensory perception of smellIEAbiological_process
GO:0002031G-protein coupled receptor internalizationIEAbiological_process
GO:0034776response to histamineIDAbiological_process
GO:0042321negative regulation of circadian sleep/wake cycle,IEAbiological_process
GO:0007195adenylate cyclase-inhibiting dopamine receptor sigIEAbiological_process
GO:0043408regulation of MAPK cascadeIEAbiological_process
GO:0050482arachidonic acid secretionIDAbiological_process
GO:0001975response to amphetamineIEAbiological_process
GO:0035255ionotropic glutamate receptor bindingIEAmolecular_function
GO:0030425dendriteISScellular_component
GO:0007409axonogenesisIEAbiological_process
GO:0021984adenohypophysis developmentIEAbiological_process
GO:0051584regulation of dopamine uptake involved in synapticIEAbiological_process
GO:0001669acrosomal vesicleIEAcellular_component
GO:0035810positive regulation of urine volumeIEAbiological_process
GO:0060160negative regulation of dopamine receptor signalingIEAbiological_process
GO:0007625grooming behaviorIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0008306associative learningIEAbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007626locomotory behaviorISSbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0001591dopamine neurotransmitter receptor activity, couplIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0002092positive regulation of receptor internalizationIEAbiological_process
GO:0042220response to cocaineISSbiological_process
GO:0031223auditory behaviorIEAbiological_process
GO:0004952dopamine neurotransmitter receptor activityIEAmolecular_function
GO:0005102receptor bindingIEAmolecular_function
GO:0001659temperature homeostasisIEAbiological_process
GO:0016328lateral plasma membraneIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0030139endocytic vesicleIEAcellular_component
GO:0006874cellular calcium ion homeostasisICbiological_process
GO:0060124positive regulation of growth hormone secretionIEAbiological_process
GO:0002027regulation of heart rateIEAbiological_process
GO:0043204perikaryonIEAcellular_component
GO:0021853cerebral cortex GABAergic interneuron migrationIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0007616long-term memoryIEAbiological_process
GO:0048755branching morphogenesis of a nerveIEAbiological_process
GO:0007270neuron-neuron synaptic transmissionIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0030900forebrain developmentIEAbiological_process
GO:0043679axon terminusIEAcellular_component
GO:0043278response to morphineIEAbiological_process
GO:0007416synapse assemblyIEAbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0051898negative regulation of protein kinase B signaling IEAbiological_process
GO:0050709negative regulation of protein secretionIDAbiological_process
GO:0032228regulation of synaptic transmission, GABAergicIEAbiological_process
GO:0043473pigmentationIEAbiological_process
GO:0032147activation of protein kinase activityIEAbiological_process
GO:0051209release of sequestered calcium ion into cytosolIEAbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0010039response to iron ionIEAbiological_process
GO:0048149behavioral response to ethanolIEAbiological_process
GO:0035240dopamine bindingIEAmolecular_function
GO:0030534adult behaviorIEAbiological_process
GO:0015459potassium channel regulator activityNASmolecular_function
GO:0030424axonIEAcellular_component
GO:0046676negative regulation of insulin secretionIEAbiological_process
GO:0008306associative learningISSbiological_process
GO:0030432peristalsisIEAbiological_process
GO:0051481reduction of cytosolic calcium ion concentrationIEAbiological_process
GO:0014854response to inactivityIEAbiological_process
GO:0007270neuron-neuron synaptic transmissionISSbiological_process
GO:0007628adult walking behaviorIEAbiological_process
GO:0030424axonISScellular_component
GO:0051586positive regulation of dopamine uptake involved inIEAbiological_process
GO:0035815positive regulation of renal sodium excretionIEAbiological_process
GO:0042417dopamine metabolic processIEAbiological_process
GO:0043266regulation of potassium ion transportIEAbiological_process
GO:0030672synaptic vesicle membraneIEAcellular_component
GO:0043666regulation of phosphoprotein phosphatase activityIEAbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recIEAbiological_process
GO:0030814regulation of cAMP metabolic processIDAbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0046717acid secretionIEAbiological_process
GO:0050804regulation of synaptic transmissionIEAbiological_process
GO:0007631feeding behaviorIEAbiological_process
GO:0008542visual learningIEAbiological_process
GO:0060134prepulse inhibitionIEAbiological_process
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0048148behavioral response to cocaineIEAbiological_process
GO:0035094response to nicotineIEAbiological_process
GO:0051584regulation of dopamine uptake involved in synapticICbiological_process
GO:0045745positive regulation of G-protein coupled receptor IEAbiological_process
GO:0048169regulation of long-term neuronal synaptic plasticiIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0009416response to light stimulusIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0032922circadian regulation of gene expressionIEAbiological_process
GO:1901386negative regulation of voltage-gated calcium channIEAbiological_process
GO:0045776negative regulation of blood pressureIEAbiological_process
GO:0002052positive regulation of neuroblast proliferationIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0051482elevation of cytosolic calcium ion concentration iIDAbiological_process