| UniProt/SwissProt ID: | FSHR_HUMAN |
| Description: | follicle stimulating hormone receptor [Source:HGNC Symbol;Acc:3969] |
| Location: | chr2 p16.3 |
| Node attribute: | GPCR; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y250 | RARSTyNLKKL | PhosphoSitePlus | |
| S218 | VFHGAsGPVIL | PhosphoSitePlus | |
| S390 | VILTTsQYKLT | 7tm_1 | PhosphoSitePlus |
| T228 | LDISRtRIHSL | PhosphoSitePlus | |
| S226 | VILDIsRTRIH | PhosphoSitePlus | |
| Dephosphorylation site |
| FSHR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000306780 | A473E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000306780 | L174V | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| FSHR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FSHR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FSHR_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| FSHR_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| FSHR_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| FSHR_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| FSHR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| FSHR_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| GLHA_HUMAN | FSHR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005768 | endosome | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042699 | follicle-stimulating hormone signaling pathway | TAS | biological_process |
| GO:0007292 | female gamete generation | TAS | biological_process |
| GO:0004963 | follicle-stimulating hormone receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0008585 | female gonad development | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0035093 | spermatogenesis, exchange of chromosomal proteins | IEA | biological_process |
| GO:0007283 | spermatogenesis | TAS | biological_process |
| GO:0033044 | regulation of chromosome organization | IEA | biological_process |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | IEA | biological_process |
| GO:0008584 | male gonad development | IEP | biological_process |
| GO:0008406 | gonad development | TAS | biological_process |
| GO:0045056 | transcytosis | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0017046 | peptide hormone binding | IEA | molecular_function |