| UniProt/SwissProt ID: | S1PR3_HUMAN |
| Description: | sphingosine-1-phosphate receptor 3 [Source:HGNC Symbol;Acc:3167] |
| Location: | chr9 q22.1 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S326 | RGARAsPIQPA | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| S1PR3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000365006 | M140V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000365006 | R311L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000365006 | R311L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000365006 | D333H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000350878 | A325T | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000365006 | M140V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000350878 | M140V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000365006 | V60A | COSMIC | Melanoma | 21499247 | ENSP00000350878 | R311L | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| S1PR3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| S1PR3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| S1PR3_HUMAN | GNA12_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR3_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR3_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR3_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR3_HUMAN | GNA13_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR3_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR3_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| S1PR3_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008289 | lipid binding | TAS | molecular_function |
| GO:0007204 | elevation of cytosolic calcium ion concentration | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | IEA | biological_process |
| GO:0009653 | anatomical structure morphogenesis | TAS | biological_process |
| GO:0038036 | sphingosine-1-phosphate receptor activity | IEA | molecular_function |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0001816 | cytokine production | IEA | biological_process |
| GO:0032651 | regulation of interleukin-1 beta production | IEA | biological_process |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |