Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:P2Y12_HUMAN
Description:purinergic receptor P2Y, G-protein coupled, 12 [Source:HGNC Symbol;Acc:18124]
Location:chr3 q25.1
Node attribute:GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T107VIFYFtMYISI7tm_1; TMPhosphoSitePlus
T264YTLSQtRDVFD7tm_1PhosphoSitePlus
S262IPYTLsQTRDV7tm_1PhosphoSitePlus
S318LKCPNsATSLSPhosphoSitePlus
Y105TSVIFyFTMYI7tm_1; TMPhosphoSitePlus

Dephosphorylation site
P2Y12_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000307259R231SCOSMICOvarian Cancer21720365
ENSP00000307259E188KBIOMARTBreast Cancer21930507, 21930502
ENSP00000307259I61VCOSMICMelanoma21499247

Differential expressed protein
P2Y12_HUMAN is not differential expressed protein.

Hyperphosphorylation site
P2Y12_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
P2Y12_HUMANGNAI1_HUMANGPCR -> GproteingpDB
P2Y12_HUMANGNAO_HUMANGPCR -> GproteingpDB
P2Y12_HUMANGNAI2_HUMANGPCR -> GproteingpDB
P2Y12_HUMANGNAI3_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
P2Y12_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007188adenylate cyclase-modulating G-protein coupled recIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0045596negative regulation of cell differentiationIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0001609G-protein coupled adenosine receptor activityIEAmolecular_function
GO:0070527platelet aggregationIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0071805potassium ion transmembrane transportIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0007599hemostasisNASbiological_process
GO:0030168platelet activationIEAbiological_process
GO:0043270positive regulation of ion transportIEAbiological_process
GO:0010700negative regulation of norepinephrine secretionIEAbiological_process
GO:0001973adenosine receptor signaling pathwayIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0051924regulation of calcium ion transportIEAbiological_process
GO:0016020membraneNAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0070588calcium ion transmembrane transportIEAbiological_process
GO:0005085guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0005901caveolaIEAcellular_component
GO:0030030cell projection organizationIEAbiological_process
GO:0009925basal plasma membraneIEAcellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0001621ADP receptor activityIEAmolecular_function


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