Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRM7_HUMAN
Description:glutamate receptor, metabotropic 7 [Source:HGNC Symbol;Acc:4599]
Location:chr3 p26.1
Node attribute:GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T12LLRVLtLMKFPPhosphoSitePlus
T675YAALLtKTNRI7tm_3; TMPhosphoSitePlus
T677ALLTKtNRIYRHPRD
T677ALLTKtNRIYR7tm_3PhosphoSitePlus
T822KLYIQtTTLTI7tm_3PhosphoSitePlus
T675YAALLtKTNRIHPRD
T264ERKDRtIDFDRANF_receptorPhosphoSitePlus
T264ERKDRtIDFDRHPRD

Dephosphorylation site
GRM7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000385664F555IBIOMARTBreast Cancer21930507, 21930502
ENSP00000350348T377MTCGAOvarian Cancer21720365, 18772890
ENSP00000384585F555IBIOMARTBreast Cancer21930507, 21930502
ENSP00000373986F555IBIOMARTBreast Cancer21930507, 21930502
ENSP00000350348T700ITCGAOvarian Cancer21720365, 18772890
ENSP00000373987F555IBIOMARTBreast Cancer21930507, 21930502
ENSP00000350348R516QTCGAOvarian Cancer21720365, 18772890
ENSP00000350348F555IBIOMARTBreast Cancer21930507, 21930502
ENSP00000350348F122LTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
GRM7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRM7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GRM7_HUMANGNAI1_HUMANGPCR -> GproteingpDB
GRM7_HUMANGNAI2_HUMANGPCR -> GproteingpDB
GRM7_HUMANGNAI3_HUMANGPCR -> GproteingpDB
GRM7_HUMANGNAO_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04724Glutamatergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030424axonISScellular_component
GO:0007268synaptic transmissionIEAbiological_process
GO:0033555multicellular organismal response to stressIEAbiological_process
GO:0045211postsynaptic membraneISScellular_component
GO:0008306associative learningIEAbiological_process
GO:0005246calcium channel regulator activityIEAmolecular_function
GO:0005509calcium ion bindingIDAmolecular_function
GO:0005938cell cortexIDAcellular_component
GO:0001661conditioned taste aversionIEAbiological_process
GO:0043198dendritic shaftISScellular_component
GO:0007613memoryIEAbiological_process
GO:0010855adenylate cyclase inhibitor activityIDAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0030818negative regulation of cAMP biosynthetic processIDAbiological_process
GO:0007605sensory perception of soundIMPbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0042734presynaptic membraneIEAcellular_component
GO:0019226transmission of nerve impulseIEAbiological_process
GO:0030165PDZ domain bindingNASmolecular_function
GO:0016595glutamate bindingIDAmolecular_function
GO:0070905serine bindingIDAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0014050negative regulation of glutamate secretionISSbiological_process
GO:0001642group III metabotropic glutamate receptor activityIDAmolecular_function
GO:0032279asymmetric synapseISScellular_component
GO:0005245voltage-gated calcium channel activityIEAmolecular_function
GO:0007608sensory perception of smellIEAbiological_process
GO:0030534adult behaviorIEAbiological_process
GO:0007614short-term memoryIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007194negative regulation of adenylate cyclase activityIDAbiological_process
GO:0008066glutamate receptor activityIDAmolecular_function
GO:0050877neurological system processIEAbiological_process
GO:0005887integral to plasma membraneNAScellular_component
GO:0001662behavioral fear responseIEAbiological_process
GO:0030425dendriteIDAcellular_component
GO:0048786presynaptic active zoneISScellular_component


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