| UniProt/SwissProt ID: | SSR5_HUMAN |
| Description: | somatostatin receptor 5 [Source:HGNC Symbol;Acc:11334] |
| Location: | chr16 p13.3 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T347 | QQQEAtPPAHR | PhosphoSitePlus | |
| S146 | VVHPLsSARWR | 7tm_1 | PhosphoSitePlus |
| S242 | CVRRRsERKVT | 7tm_1 | PhosphoSitePlus |
| S147 | VHPLSsARWRR | 7tm_1 | PhosphoSitePlus |
| T247 | SERKVtRMVLV | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| SSR5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000380680 | N81S | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| SSR5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SSR5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SMS_HUMAN | SSR5_HUMAN | ligand -> receptor | HPMR |
| CORT_HUMAN | SSR5_HUMAN | ligand -> receptor | HPMR |
| SSR5_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| SSR5_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| SSR5_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| SSR5_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004994 | somatostatin receptor activity | IEA | molecular_function |
| GO:0050796 | regulation of insulin secretion | IEA | biological_process |
| GO:0042593 | glucose homeostasis | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0038170 | somatostatin signaling pathway | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |