| UniProt/SwissProt ID: | TBB2B_HUMAN |
| Description: | tubulin, beta 2B class IIb [Source:HGNC Symbol;Acc:30829] |
| Location: | chr6 p25.2 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S230 | LNHLVsATMSG | PhosphoSitePlus | |
| Y340 | NKNSSyFVEWI | Tubulin_C | PhosphoSitePlus |
| T219 | TLKLTtPTYGD | Tubulin | PhosphoSitePlus |
| S382 | LFKRIsEQFTA | Tubulin_C | PhosphoSitePlus |
| Y200 | NTDETyCIDNE | Tubulin | PhosphoSitePlus |
| T221 | KLTTPtYGDLN | Tubulin | PhosphoSitePlus |
| Y50 | ERINVyYNEAT | Tubulin | PhosphoSitePlus |
| T218 | RTLKLtTPTYG | Tubulin | PhosphoSitePlus |
| S115 | AELVDsVLDVV | Tubulin | PhosphoSitePlus |
| Y36 | DPTGSyHGDSD | Tubulin | PhosphoSitePlus |
| S78 | MDSVRsGPFGQ | Tubulin | PhosphoSitePlus |
| Y281 | RGSQQyRALTV | Tubulin_C | PhosphoSitePlus |
| Y106 | WAKGHyTEGAE | Tubulin | PhosphoSitePlus |
| T107 | AKGHYtEGAEL | Tubulin | PhosphoSitePlus |
| Y222 | LTTPTyGDLNH | Tubulin | PhosphoSitePlus |
| S322 | FRGRMsMKEVD | Tubulin_C | PhosphoSitePlus |
| T196 | QLVENtDETYC | Tubulin | PhosphoSitePlus |
| S339 | QNKNSsYFVEW | Tubulin_C | PhosphoSitePlus |
| S275 | FAPLTsRGSQQ | Tubulin_C | PhosphoSitePlus |
| Y183 | TVVEPyNATLS | Tubulin | PhosphoSitePlus |
| Y208 | DNEALyDICFR | Tubulin | PhosphoSitePlus |
| S338 | VQNKNsSYFVE | Tubulin_C | PhosphoSitePlus |
| S168 | IMNTFsVMPSP | HPRD | |
| T366 | LKMSAtFIGNS | Tubulin_C | PhosphoSitePlus |
| T290 | TVPELtQQMFD | Tubulin_C | PhosphoSitePlus |
| T274 | GFAPLtSRGSQ | Tubulin_C | PhosphoSitePlus |
| S35 | IDPTGsYHGDS | HPRD | |
| S75 | PGTMDsVRSGP | Tubulin | PhosphoSitePlus |
| T33 | HGIDPtGSYHG | HPRD | |
| S95 | FVFGQsGAGNN | Tubulin | PhosphoSitePlus |
| T199 | ENTDEtYCIDN | Tubulin | PhosphoSitePlus |
| Y159 | KIREEyPDRIM | Tubulin | PhosphoSitePlus |
| S278 | LTSRGsQQYRA | Tubulin_C | PhosphoSitePlus |
| Dephosphorylation site |
| TBB2B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000259818 | E444K | COSMIC | Skin Cancer | 21984974 | ENSP00000259818 | E444K | COSMIC | Skin Cancer | 21984974 | ENSP00000259818 | E444K | COSMIC | Skin Cancer | 21984974 | ENSP00000259818 | E444K | COSMIC | Skin Cancer | 21984974 | ENSP00000259818 | E444K | COSMIC | Skin Cancer | 21984974 | ENSP00000259818 | R62W | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000259818 | E444K | COSMIC | Skin Cancer | 21984974 | ENSP00000259818 | E444K | COSMIC | Skin Cancer | 21984974 | ENSP00000259818 | E444K | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000259818 | Hepatocellular Carcinoma | Metastasis | cell line | Down | 17214954 | ENSP00000259818 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Up | 2.5 | 20804217 |
| Hyperphosphorylation site |
| TBB2B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG5_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GNAI2_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBG12_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBG10_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GNAI3_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GNAS1_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GNAS2_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GNAI1_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GNAO_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| GNAQ_HUMAN | TBB2B_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04145 | Phagosome |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa04540 | Gap junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051258 | protein polymerization | IEA | biological_process |
| GO:0005198 | structural molecule activity | IEA | molecular_function |
| GO:0007018 | microtubule-based movement | IEA | biological_process |
| GO:0001764 | neuron migration | IMP | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0001764 | neuron migration | IEA | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005874 | microtubule | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0051084 | 'de novo' posttranslational protein folding | TAS | biological_process |
| GO:0015630 | microtubule cytoskeleton | IDA | cellular_component |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0006457 | protein folding | TAS | biological_process |