Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCR2_HUMAN
Description:chemokine (C-C motif) receptor 2 [Source:HGNC Symbol;Acc:1603]
Location:chr3 p21.31
Node attribute:substrate; GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y139LTIDRyLAIVH7tm_1PhosphoSitePlus
Y139LTIDRyLAIVHJAK2phosphoELM; RegPhos

Dephosphorylation site
CCR2_HUMAN do not have dephosphorylation site.

Mutation site
CCR2_HUMAN do not have mutation site.

Differential expressed protein
CCR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCL13_HUMANCCR2_HUMANligand -> receptorHPMR
CCL2_HUMANCCR2_HUMANligand -> receptorHPMR
CCL16_HUMANCCR2_HUMANligand -> receptorHPMR
CCL7_HUMANCCR2_HUMANligand -> receptorHPMR
CCR2_HUMANGNAI1_HUMANGPCR -> GproteingpDB
CCR2_HUMANGNAI3_HUMANGPCR -> GproteingpDB
CCR2_HUMANGNAI2_HUMANGPCR -> GproteingpDB
CCR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
JAK2_HUMANCCR2_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
CCL13_HUMANCCR2_HUMANotherKEGG
CCL2_HUMANCCR2_HUMANotherKEGG
CCL7_HUMANCCR2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0016493C-C chemokine receptor activityIEAmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0004950chemokine receptor activityTASmolecular_function
GO:0043204perikaryonISScellular_component
GO:0007194negative regulation of adenylate cyclase activityTASbiological_process
GO:0010574regulation of vascular endothelial growth factor pISSbiological_process
GO:0070098chemokine-mediated signaling pathwayISSbiological_process
GO:0006874cellular calcium ion homeostasisISSbiological_process
GO:0006955immune responseTASbiological_process
GO:0050870positive regulation of T cell activationISSbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0002407dendritic cell chemotaxisTASbiological_process
GO:0050729positive regulation of inflammatory responseISSbiological_process
GO:0006968cellular defense responseTASbiological_process
GO:0002829negative regulation of type 2 immune responseISSbiological_process
GO:0005829cytosolISScellular_component
GO:2000464positive regulation of astrocyte chemotaxisIDAbiological_process
GO:0019725cellular homeostasisISSbiological_process
GO:0048471perinuclear region of cytoplasmISScellular_component
GO:0046641positive regulation of alpha-beta T cell proliferaISSbiological_process
GO:0035705T-helper 17 cell chemotaxisISSbiological_process
GO:0002827positive regulation of T-helper 1 type immune respISSbiological_process
GO:2000451positive regulation of CD8-positive, alpha-beta T ISSbiological_process
GO:0019221cytokine-mediated signaling pathwayIDAbiological_process
GO:2000473positive regulation of hematopoietic stem cell migISSbiological_process
GO:0090265positive regulation of immune complex clearance byISSbiological_process
GO:0032729positive regulation of interferon-gamma productionISSbiological_process
GO:0045087innate immune responseTASbiological_process
GO:2000439positive regulation of monocyte extravasationISSbiological_process
GO:0009611response to woundingTASbiological_process
GO:0006935chemotaxisTASbiological_process
GO:0016525negative regulation of angiogenesisISSbiological_process
GO:0043025neuronal cell bodyISScellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0010820positive regulation of T cell chemotaxisISSbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0090026positive regulation of monocyte chemotaxisISSbiological_process
GO:0030425dendriteISScellular_component
GO:0006954inflammatory responseTASbiological_process
GO:0042535positive regulation of tumor necrosis factor biosyISSbiological_process
GO:0001974blood vessel remodelingISSbiological_process
GO:0031727CCR2 chemokine receptor bindingIDAmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process
GO:0032743positive regulation of interleukin-2 productionISSbiological_process
GO:0042803protein homodimerization activityISSmolecular_function
GO:0043310negative regulation of eosinophil degranulationISSbiological_process