| UniProt/SwissProt ID: | CXCR6_HUMAN |
| Description: | chemokine (C-X-C motif) receptor 6 [Source:HGNC Symbol;Acc:16647] |
| Location: | chr3 p21.31 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y182 | KLICGyHDEAI | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| CXCR6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000396218 | L312F | COSMIC | Melanoma | ENSP00000304414 | L312F | COSMIC | Melanoma | ENSP00000396886 | L312F | COSMIC | Melanoma | ENSP00000395704 | L312F | COSMIC | Melanoma |
| Differential expressed protein |
| CXCR6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CXCR6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CXL16_HUMAN | CXCR6_HUMAN | ligand -> receptor | HPMR |
| CXCR6_HUMAN | GNAO_HUMAN | GPCR -> Gprotein | gpDB |
| CXCR6_HUMAN | GNAI1_HUMAN | GPCR -> Gprotein | gpDB |
| CXCR6_HUMAN | GNAI3_HUMAN | GPCR -> Gprotein | gpDB |
| CXCR6_HUMAN | GNAI2_HUMAN | GPCR -> Gprotein | gpDB |
| CXL16_HUMAN | CXCR6_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa04062 | Chemokine signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019079 | viral genome replication | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016494 | C-X-C chemokine receptor activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0015026 | coreceptor activity | TAS | molecular_function |