Phosphorylation

Protein information

UniProt/SwissProt ID:	RAC3_HUMAN
Description:	ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [Source:HGNC Symbol;Acc:9803]
Location:	chr17 q25.3
Node attribute:	effector

Position	PhosphoPeptide	Catalytic kinase	Source
Y64	AGQEDyDRLRP	Ras	PhosphoSitePlus
T161	ECSALtQRGLK	Ras	PhosphoSitePlus
T167	QRGLKtVFDEA	Ras	PhosphoSitePlus
S89	LVSPAsFENVR	Ras	PhosphoSitePlus
Y139	LAPITyPQGLA	Ras	PhosphoSitePlus

RAC3_HUMAN do not have dephosphorylation site.

RAC3_HUMAN do not have mutation site.

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000304283	Testicular Cancer	Normal vs. Cancer	cell line	Down		18489135

RAC3_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
GNAI2_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBG8_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBB2_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBG12_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBG13_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBG10_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBG2_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBG1_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBB3_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBB5_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GNAI3_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBG5_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GNAI1_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBG11_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBB1_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB
GBG3_HUMAN	RAC3_HUMAN	Gprotein -> effector	gpDB

KEGG Pathway

KEGG ID	Pathway
hsa05200	Pathways in cancer
hsa04370	VEGF signaling pathway
hsa04310	Wnt signaling pathway
hsa05210	Colorectal cancer
hsa04662	B cell receptor signaling pathway
hsa04360	Axon guidance
hsa04520	Adherens junction
hsa04650	Natural killer cell mediated cytotoxicity
hsa05416	Viral myocarditis
hsa04010	MAPK signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa05212	Pancreatic cancer
hsa04510	Focal adhesion
hsa04664	Fc epsilon RI signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0005886	plasma membrane	TAS	cellular_component
GO:0030031	cell projection assembly	IDA	biological_process
GO:0051056	regulation of small GTPase mediated signal transdu	TAS	biological_process
GO:0012505	endomembrane system	IDA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0015031	protein transport	IEA	biological_process
GO:0005525	GTP binding	IEA	molecular_function
GO:0006184	GTP catabolic process	IDA	biological_process
GO:0050885	neuromuscular process controlling balance	IEA	biological_process
GO:0031941	filamentous actin	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0031175	neuron projection development	IEA	biological_process
GO:0030426	growth cone	IDA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0030036	actin cytoskeleton organization	IDA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0043005	neuron projection	IDA	cellular_component
GO:0035556	intracellular signal transduction	TAS	biological_process
GO:0007165	signal transduction	IEA	biological_process
GO:0003924	GTPase activity	IDA	molecular_function
GO:0030027	lamellipodium	IEA	cellular_component
GO:0007264	small GTPase mediated signal transduction	IEA	biological_process
GO:0050905	neuromuscular process	IEA	biological_process
GO:0043025	neuronal cell body	IDA	cellular_component

Human Phosphorylation Mediated
Signaling Transduction Network