Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EDNRB_HUMAN
Description:endothelin receptor type B [Source:HGNC Symbol;Acc:3180]
Location:chr13 q22.3
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y430ANDHGyDNFRSPhosphoSitePlus; HPRD
S413FEEKQsLEEKQHPRD
S440SSNKYsHPRD
S407CCWCQsFEEKQPhosphoSitePlus; HPRD
S305MLRKKsGMQIAHPRD
S305MLRKKsGMQIA7tm_1PhosphoSitePlus
S440SSNKYsSS___PhosphoSitePlus
S442NKYSSs_____PhosphoSitePlus
S419LEEKQsCLKFKPhosphoSitePlus; HPRD
S441SNKYSHPRD
S436DNFRSsNKYSSPhosphoSitePlus
Y200LSIDRyRAVASHPRD
Y200LSIDRyRAVAS7tm_1PhosphoSitePlus
S435YDNFRsSNKYSPhosphoSitePlus; HPRD
Y439RSSNKySHPRD
S205YRAVAsWSRIK7tm_1PhosphoSitePlus
Y439RSSNKySSS__PhosphoSitePlus
S205YRAVAsWSRIKHPRD
S436DNFRSsNKYSHPRD
S442NKYSHPRD
T52TPPTKtLWPKGPhosphoSitePlus
S441SNKYSsS____PhosphoSitePlus
S80DRTAGsPPRTIPhosphoSitePlus

Dephosphorylation site
EDNRB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000335311Y387HBIOMARTBreast Cancer21930507, 21930502
ENSP00000335311R343KCOSMICSkin Cancer21984974
ENSP00000403401Y387HBIOMARTBreast Cancer21930507, 21930502
ENSP00000335311W217*COSMICSkin Cancer21984974

Differential expressed protein
EDNRB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EDNRB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EDN3_HUMANEDNRB_HUMANligand -> receptorHPMR
EDNRB_HUMANGNAI1_HUMANGPCR -> GproteingpDB
EDNRB_HUMANGNA12_HUMANGPCR -> GproteingpDB
EDNRB_HUMANGNA11_HUMANGPCR -> GproteingpDB
EDNRB_HUMANGNAO_HUMANGPCR -> GproteingpDB
EDNRB_HUMANGNAI2_HUMANGPCR -> GproteingpDB
EDNRB_HUMANGNAI3_HUMANGPCR -> GproteingpDB
EDNRB_HUMANGNA13_HUMANGPCR -> GproteingpDB
EDNRB_HUMANGNAQ_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04916Melanogenesis
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048484enteric nervous system developmentISSbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0042310vasoconstrictionIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0050678regulation of epithelial cell proliferationIEAbiological_process
GO:0007194negative regulation of adenylate cyclase activityTASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0042310vasoconstrictionIMPbiological_process
GO:0048484enteric nervous system developmentIEAbiological_process
GO:0032269negative regulation of cellular protein metabolic IMPbiological_process
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0017046peptide hormone bindingIPImolecular_function
GO:0001755neural crest cell migrationIEAbiological_process
GO:0051930regulation of sensory perception of painIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0048066developmental pigmentationIEAbiological_process
GO:0014043negative regulation of neuron maturationISSbiological_process
GO:0007497posterior midgut developmentIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0004962endothelin receptor activityIEAmolecular_function
GO:0031702type 1 angiotensin receptor bindingIEAmolecular_function
GO:0019233sensory perception of painIEAbiological_process
GO:0007399nervous system developmentTASbiological_process
GO:0043473pigmentationIEAbiological_process
GO:0086100endothelin receptor signaling pathwayIDAbiological_process
GO:0031965nuclear membraneIEAcellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0004962endothelin receptor activityIDAmolecular_function
GO:0014043negative regulation of neuron maturationIEAbiological_process
GO:0060406positive regulation of penile erectionIEAbiological_process
GO:0019934cGMP-mediated signalingIEAbiological_process
GO:0007422peripheral nervous system developmentIEAbiological_process
GO:0008217regulation of blood pressureIEAbiological_process
GO:0014826vein smooth muscle contractionIMPbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0006885regulation of pHIEAbiological_process
GO:0035645enteric smooth muscle cell differentiationISSbiological_process
GO:0048246macrophage chemotaxisIMPbiological_process
GO:0035810positive regulation of urine volumeIEAbiological_process
GO:0042045epithelial fluid transportIEAbiological_process
GO:0035815positive regulation of renal sodium excretionIEAbiological_process
GO:0035645enteric smooth muscle cell differentiationIEAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0048265response to painIEAbiological_process
GO:0042311vasodilationIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0030318melanocyte differentiationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007568agingIEAbiological_process