Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCR8_HUMAN
Description:chemokine (C-C motif) receptor 8 [Source:HGNC Symbol;Acc:1609]
Location:chr3 p22.2
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y132MSVDRyLAVVH7tm_1PhosphoSitePlus
S340CEKSSsCQQHSPhosphoSitePlus
S338ESCEKsSSCQQPhosphoSitePlus
S339SCEKSsSCQQHPhosphoSitePlus

Dephosphorylation site
CCR8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000326432N232KCOSMICOvarian Cancer21720365
ENSP00000326432I69NBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000326432N232KTCGAOvarian Cancer21720365, 18772890
ENSP00000326432E333KCOSMICLung Cancer20668451

Differential expressed protein
CCR8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCR8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCL1_HUMANCCR8_HUMANligand -> receptorHPMR
CCR8_HUMANGNAI1_HUMANGPCR -> GproteingpDB
CCR8_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR8_HUMANGNAI3_HUMANGPCR -> GproteingpDB
CCR8_HUMANGNAI2_HUMANGPCR -> GproteingpDB
CCL1_HUMANCCR8_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneIEAcellular_component
GO:0004950chemokine receptor activityTASmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0006935chemotaxisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006955immune responseTASbiological_process
GO:0070098chemokine-mediated signaling pathwayTASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0016493C-C chemokine receptor activityIEAmolecular_function
GO:0015026coreceptor activityTASmolecular_function


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