| UniProt/SwissProt ID: | GNAI1_HUMAN |
| Description: | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 [Source:HGNC Symbol;Acc:4384] |
| Location: | chr7 q21.11 |
| Node attribute: | Gprotein |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y320 | DTKEIyTHFTC | G-alpha | PhosphoSitePlus |
| Y155 | DSAAYyLNDLD | G-alpha | PhosphoSitePlus |
| Dephosphorylation site |
| GNAI1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000343027 | E289Q | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000343027 | D309Y | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000343027 | D193N | COSMIC | Central Nervous System Neoplasms | 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000343027 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| GNAI1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04726 | Serotonergic synapse |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04916 | Melanogenesis |
| hsa04670 | Leukocyte transendothelial migration |
| hsa05030 | Cocaine addiction |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa04724 | Glutamatergic synapse |
| hsa04725 | Cholinergic synapse |
| hsa04062 | Chemokine signaling pathway |
| hsa05133 | Pertussis |
| hsa04971 | Gastric acid secretion |
| hsa04360 | Axon guidance |
| hsa05145 | Toxoplasmosis |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa04728 | Dopaminergic synapse |
| hsa04540 | Gap junction |
| hsa05032 | Morphine addiction |
| hsa04730 | Long-term depression |
| hsa05034 | Alcoholism |
| hsa04727 | GABAergic synapse |
| hsa04530 | Tight junction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006906 | vesicle fusion | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0051301 | cell division | IMP | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0030496 | midbody | IDA | cellular_component |
| GO:0045121 | membrane raft | IEA | cellular_component |
| GO:0019001 | guanyl nucleotide binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | TAS | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0043434 | response to peptide hormone stimulus | ISS | biological_process |
| GO:0003924 | GTPase activity | IBA | molecular_function |
| GO:0031234 | extrinsic to internal side of plasma membrane | IBA | cellular_component |
| GO:0006184 | GTP catabolic process | IBA | biological_process |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0042588 | zymogen granule | IEA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0031821 | G-protein coupled serotonin receptor binding | IEA | molecular_function |
| GO:0031683 | G-protein beta/gamma-subunit complex binding | IBA | molecular_function |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0031821 | G-protein coupled serotonin receptor binding | IBA | molecular_function |
| GO:0005834 | heterotrimeric G-protein complex | IBA | cellular_component |