Phosphorylation

You are querying signaling transduction network mediated by ACVR1_HUMAN in Colorectal Cancer.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	BMP7_HUMAN	ACVR1_HUMAN	ligand -> receptor	HPMR
2	BMP6_HUMAN	ACVR1_HUMAN	ligand -> receptor	HPMR
3	ACVR1_HUMAN	RIPK3_HUMAN	kinase -> substrate	Robert H Newman (2013)
4	ACVR1_HUMAN	FGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
5	ACVR1_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
6	ACVR1_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
7	ACVR1_HUMAN	SMAD3_HUMAN	kinase -> substrate	Robert H Newman (2013)
8	ACVR1_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
9	ACVR1_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
10	RIPK3_HUMAN	MK01_HUMAN	kinase -> substrate	Robert H Newman (2013)
11	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
12	FGR_HUMAN	MK01_HUMAN	kinase -> substrate	Robert H Newman (2013)
13	KS6A2_HUMAN	EF2K_HUMAN	kinase -> substrate	RegPhos
14	KS6A2_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
15	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
16	ETS1_HUMAN	NFKB1_HUMAN	TF -> target gene	TRANSFAC
17	FGR_HUMAN	SRC_HUMAN	kinase -> substrate	HPRD; RegPhos
18	SMAD3_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
19	FGR_HUMAN	HNRPK_HUMAN	kinase -> substrate	Robert H Newman (2013)
20	KS6A2_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
21	ETS1_HUMAN	AP2A_HUMAN	TF -> target gene	TRANSFAC
22	KS6A2_HUMAN	FOS_HUMAN	kinase -> substrate	RegPhos
23	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
24	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
25	ETS1_HUMAN	CSK2B_HUMAN	TF -> target gene	TRANSFAC
26	KS6A2_HUMAN	ESR1_HUMAN	kinase -> substrate	RegPhos
27	KS6A2_HUMAN	CSK_HUMAN	kinase -> substrate	Robert H Newman (2013)
28	KS6A2_HUMAN	NR4A1_HUMAN	kinase -> substrate	RegPhos
29	KS6A2_HUMAN	SRF_HUMAN	kinase -> substrate	RegPhos
30	RIPK3_HUMAN	E2AK2_HUMAN	kinase -> substrate	Robert H Newman (2013)
31	KS6A2_HUMAN	KS6A1_HUMAN	kinase -> substrate	RegPhos
32	KS6A2_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
33	RIPK3_HUMAN	RIPK1_HUMAN	kinase -> substrate	NetPath
34	KS6A2_HUMAN	KKCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
35	KS6A2_HUMAN	CSEN_HUMAN	kinase -> substrate	Robert H Newman (2013)
36	KS6A2_HUMAN	GABPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
37	KS6A2_HUMAN	CEBPB_HUMAN	kinase -> substrate	RegPhos
38	MK01_HUMAN	SP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
39	CSK21_HUMAN	SP1_HUMAN	kinase -> substrate	HPRD
40	MK01_HUMAN	STK16_HUMAN	kinase -> substrate	Robert H Newman (2013)
41	EF2K_HUMAN	AAPK1_HUMAN	kinase -> substrate	Robert H Newman (2013)
42	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
43	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
44	MK01_HUMAN	BCL6_HUMAN	kinase -> substrate	NetPath
45	SRC_HUMAN	AKT1_HUMAN	kinase -> substrate	RegPhos
46	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
47	JUN_HUMAN	P53_HUMAN	TF -> target gene	TRANSFAC
48	SRC_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos
49	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
50	TF65_HUMAN	P53_HUMAN	TF -> target gene	TRANSFAC
51	AP2A_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
52	MK01_HUMAN	TFE2_HUMAN	kinase -> substrate	HPRD; NetPath
53	CSK21_HUMAN	SRPK1_HUMAN	kinase -> substrate	Robert H Newman (2013)
54	FOS_HUMAN	MLTK_HUMAN	TF -> target gene	TRANSFAC
55	AP2A_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
56	MK01_HUMAN	STF1_HUMAN	kinase -> substrate	HPRD
57	CSK21_HUMAN	PRGR_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
58	CSK21_HUMAN	AKT1_HUMAN	kinase -> substrate	Robert H Newman (2013)
59	MK01_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
60	MK01_HUMAN	PRGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
61	CSK21_HUMAN	MYC_HUMAN	kinase -> substrate	HPRD
62	JUN_HUMAN	MLTK_HUMAN	TF -> target gene	TRANSFAC
63	FOS_HUMAN	P53_HUMAN	TF -> target gene	TRANSFAC
64	MK01_HUMAN	SRBP2_HUMAN	kinase -> substrate	Robert H Newman (2013)
65	MK01_HUMAN	STA5A_HUMAN	kinase -> substrate	Robert H Newman (2013)
66	MK01_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
67	MK01_HUMAN	THB_HUMAN	kinase -> substrate	Robert H Newman (2013)
68	CSK2B_HUMAN	P53_HUMAN	kinase -> substrate	HPRD
69	MK01_HUMAN	MYC_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
70	MK01_HUMAN	MITF_HUMAN	kinase -> substrate	NetPath
71	MK01_HUMAN	PKN1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
72	CSK_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
73	CSK21_HUMAN	VDR_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
74	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
75	MK01_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD
76	MK01_HUMAN	P53_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
77	SRF_HUMAN	ELK1_HUMAN	TF -> target gene	TRANSFAC
78	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
79	CSK21_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
80	E2AK2_HUMAN	P53_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
81	KS6A1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	AP2A_HUMAN	MLTK_HUMAN	TF -> target gene	TRANSFAC
83	MK01_HUMAN	PPARA_HUMAN	kinase -> substrate	HPRD
84	MK01_HUMAN	ANDR_HUMAN	kinase -> substrate	HPRD
85	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
86	JUN_HUMAN	ATF3_HUMAN	TF -> target gene	TRANSFAC
87	CSK21_HUMAN	CDK1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
88	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
89	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
90	CREB1_HUMAN	MITF_HUMAN	TF -> target gene	TRANSFAC
91	SRC_HUMAN	STA5B_HUMAN	kinase -> substrate	HPRD; RegPhos
92	E2AK2_HUMAN	PLK1_HUMAN	kinase -> substrate	Robert H Newman (2013)
93	FOS_HUMAN	WEE1_HUMAN	TF -> target gene	TRANSFAC
94	RIPK1_HUMAN	M3K1_HUMAN	kinase -> substrate	NetPath
95	SRC_HUMAN	PDPK1_HUMAN	kinase -> substrate	RegPhos
96	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
97	KKCC1_HUMAN	AKT1_HUMAN	kinase -> substrate	HPRD
98	MK01_HUMAN	PTPRR_HUMAN	kinase -> substrate	HPRD
99	ENOA_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
100	ESR1_HUMAN	PRGR_HUMAN	TF -> target gene	TRANSFAC
101	SRC_HUMAN	RHG35_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
102	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
103	MK01_HUMAN	SOS1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
104	SRC_HUMAN	CTNB1_HUMAN	kinase -> substrate	RegPhos
105	CSK2B_HUMAN	CTNB1_HUMAN	kinase -> substrate	HPRD
106	CSK21_HUMAN	MYB_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
107	CSK_HUMAN	FYN_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
108	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
109	MK01_HUMAN	SRBP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
110	MK01_HUMAN	MYB_HUMAN	kinase -> substrate	HPRD
111	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
112	MK01_HUMAN	ELK1_HUMAN	kinase -> substrate	NetPath
113	MK01_HUMAN	MAPK5_HUMAN	kinase -> substrate	Robert H Newman (2013)
114	KKCC1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
115	MK01_HUMAN	CEBPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
116	CSK21_HUMAN	P53_HUMAN	kinase -> substrate	HPRD
117	SRC_HUMAN	ABL1_HUMAN	kinase -> substrate	RegPhos
118	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
119	MK01_HUMAN	ELK4_HUMAN	kinase -> substrate	KEGG
120	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
121	CSK21_HUMAN	HSF1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
122	KS6A1_HUMAN	MITF_HUMAN	kinase -> substrate	NetPath
123	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
124	CSK21_HUMAN	CTNB1_HUMAN	kinase -> substrate	HPRD
125	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
126	AP2A_HUMAN	ATF2_HUMAN	TF -> target gene	TRANSFAC
127	CSK21_HUMAN	MK09_HUMAN	kinase -> substrate	Robert H Newman (2013)
128	SRC_HUMAN	IKKA_HUMAN	kinase -> substrate	NetPath
129	CSK_HUMAN	ANDR_HUMAN	kinase -> substrate	RegPhos
130	CSK21_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
131	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
132	SP1_HUMAN	AP2C_HUMAN	TF -> target gene	TRANSFAC
133	SP1_HUMAN	SP3_HUMAN	TF -> target gene	TRANSFAC
134	STK16_HUMAN	IRF5_HUMAN	kinase -> substrate	Robert H Newman (2013)
135	AAPK1_HUMAN	CDK2_HUMAN	kinase -> substrate	Robert H Newman (2013)
136	AKT1_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos
137	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
138	SP1_HUMAN	PHX2A_HUMAN	TF -> target gene	TRANSFAC
139	SRPK1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
140	MLTK_HUMAN	MP2K7_HUMAN	kinase -> substrate	KEGG
141	AKT1_HUMAN	MK08_HUMAN	kinase -> substrate	Robert H Newman (2013)
142	PTN7_HUMAN	MK08_HUMAN	phosphatase -> substrate	KEGG
143	SP1_HUMAN	RARA_HUMAN	TF -> target gene	TRANSFAC
144	P53_HUMAN	P63_HUMAN	TF -> target gene	TRANSFAC
145	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
146	P53_HUMAN	BBC3_HUMAN	TF -> target gene	TRANSFAC
147	SP1_HUMAN	CDK2_HUMAN	TF -> target gene	TRANSFAC
148	P53_HUMAN	P73_HUMAN	TF -> target gene	KEGG; TRANSFAC
149	SP1_HUMAN	TGFR2_HUMAN	TF -> target gene	TRANSFAC
150	AKT1_HUMAN	SOX9_HUMAN	kinase -> substrate	Robert H Newman (2013)
151	AKT1_HUMAN	THA_HUMAN	kinase -> substrate	Robert H Newman (2013)
152	CDK1_HUMAN	CDK7_HUMAN	kinase -> substrate	RegPhos
153	AKT1_HUMAN	GATA1_HUMAN	kinase -> substrate	HPRD; RegPhos
154	EGR1_HUMAN	TGFR2_HUMAN	TF -> target gene	TRANSFAC
155	PLK1_HUMAN	MK08_HUMAN	kinase -> substrate	Robert H Newman (2013)
156	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
157	WEE1_HUMAN	CDK2_HUMAN	kinase -> substrate	HPRD
158	M3K1_HUMAN	MP2K7_HUMAN	kinase -> substrate	RegPhos
159	PDPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
160	AAPK1_HUMAN	MK08_HUMAN	kinase -> substrate	Robert H Newman (2013)
161	PTPRR_HUMAN	MK07_HUMAN	phosphatase -> substrate	HPRD
162	AKT1_HUMAN	TEAD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
163	FYN_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
164	AKT1_HUMAN	GATA2_HUMAN	kinase -> substrate	HPRD
165	MAPK5_HUMAN	MK08_HUMAN	kinase -> substrate	Robert H Newman (2013)
166	SRPK1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
167	AKT1_HUMAN	STAT6_HUMAN	kinase -> substrate	Robert H Newman (2013)
168	CDK1_HUMAN	CUX1_HUMAN	kinase -> substrate	RegPhos
169	ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
170	CDK1_HUMAN	HMGA2_HUMAN	kinase -> substrate	RegPhos
171	PKN1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
172	FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
173	MK09_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
174	IKKA_HUMAN	IRF7_HUMAN	kinase -> substrate	KEGG
175	ABL1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
176	CDK1_HUMAN	P73_HUMAN	kinase -> substrate	HPRD; RegPhos
177	CDK2_HUMAN	NFYA_HUMAN	kinase -> substrate	HPRD
178	CDK2_HUMAN	TFDP1_HUMAN	kinase -> substrate	RegPhos
179	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
180	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
181	MP2K7_HUMAN	M3K7_HUMAN	kinase -> substrate	KEGG
182	MK08_HUMAN	DYR1B_HUMAN	kinase -> substrate	Robert H Newman (2013)
183	MK08_HUMAN	PAX2_HUMAN	kinase -> substrate	NetPath
184	MK08_HUMAN	NFAC2_HUMAN	kinase -> substrate	KEGG
185	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
186	TGFR2_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
187	CDK7_HUMAN	PO2F1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
188	MK07_HUMAN	MEF2D_HUMAN	kinase -> substrate	HPRD
189	MK08_HUMAN	JUND_HUMAN	kinase -> substrate	KEGG
190	CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
191	M3K7_HUMAN	FUBP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
192	DYR1B_HUMAN	HNF1A_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
193	M3K7_HUMAN	NLK_HUMAN	kinase -> substrate	KEGG
194	NFAC2_HUMAN	EGR3_HUMAN	TF -> target gene	TRANSFAC
195	NLK_HUMAN	LEF1_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
196	ACVR1_HUMAN	WWP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
197	ACVR1_HUMAN	OTU7B_HUMAN	kinase -> substrate	Robert H Newman (2013)
198	ACVR1_HUMAN	SMAD1_HUMAN	kinase -> substrate	HPRD
199	ACVR1_HUMAN	MCM5_HUMAN	kinase -> substrate	Robert H Newman (2013)
200	ACVR1_HUMAN	RNF14_HUMAN	kinase -> substrate	Robert H Newman (2013)
201	ACVR1_HUMAN	ZBT44_HUMAN	kinase -> substrate	Robert H Newman (2013)
202	ACVR1_HUMAN	MDM2_HUMAN	kinase -> substrate	Robert H Newman (2013)
203	ACVR1_HUMAN	TIF1A_HUMAN	kinase -> substrate	Robert H Newman (2013)
204	ACVR1_HUMAN	GA45A_HUMAN	kinase -> substrate	Robert H Newman (2013)
205	ACVR1_HUMAN	DNJB2_HUMAN	kinase -> substrate	Robert H Newman (2013)
206	ACVR1_HUMAN	SMAD2_HUMAN	kinase -> substrate	KEGG
207	ACVR1_HUMAN	E2F3_HUMAN	kinase -> substrate	Robert H Newman (2013)
208	ACVR1_HUMAN	ORC1_HUMAN	kinase -> substrate	Robert H Newman (2013)

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network