Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK09_HUMAN
Description:mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:6886]
Location:chr5 q35.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T183TNFMMtPYVVTPkinasePhosphoSitePlus
T404MSTEQtLASDTPhosphoSitePlus
T404MSTEQtLASDTCK2_alphaphosphoELM
T404MSTEQtLASDTCK2a1(CK2 alphaRegPhos
T183TNFMMtPYVVTphosphoELM; RegPhos
Y357WKELIyKEVMDDUF1651PhosphoSitePlus
S407EQTLAsDTDSSPhosphoSitePlus
T404MSTEQtLASDTMAP2K7HPRD; phosphoELM; RegPhos
S407EQTLAsDTDSSCK2_alphaphosphoELM
S407EQTLAsDTDSSCK2a1(CK2 alphaRegPhos
Y185FMMTPyVVTRYphosphoELM; RegPhos
S155RDLKPsNIVVKPkinasePhosphoSitePlus
T178ARTACtNFMMTPkinasePhosphoSitePlus
S292DKIKTsQARDLPkinasePhosphoSitePlus
T188TPYVVtRYYRAPkinasePhosphoSitePlus
S407EQTLAsDTDSSMAP2K_groupphosphoELM; RegPhos
T183TNFMMtPYVVTMAP2K7HPRD; phosphoELM; RegPhos
Y185FMMTPyVVTRYRETHPRD; RegPhos
S407EQTLAsDTDSSMAP2K7HPRD; phosphoELM; RegPhos
Y185FMMTPyVVTRYMAP2K4HPRD; phosphoELM; RegPhos
Y185FMMTPyVVTRYMAP2K7HPRD; RegPhos
T404MSTEQtLASDTMAP2K_groupphosphoELM; RegPhos
Y185FMMTPyVVTRYPkinasePhosphoSitePlus

Dephosphorylation site
MK09_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000394560N90SCOSMICOvarian Cancer21720365
ENSP00000394560V13MHPIColorectal Cancer17344846
ENSP00000394560H143LCOSMICHead and Neck Cancer21798893
ENSP00000394560K56NHPIHead and Neck Cancer17344846
ENSP00000394560S12GCOSMICGastric Cancer21097718

Differential expressed protein
MK09_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MK09_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK09_HUMANRUVB1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K7_HUMANMK09_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANHNRL1_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMAN3BP5_HUMANkinase -> substrateRegPhos
MK09_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANJDP2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK09_HUMANRFA2_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANELK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANFOXO4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMK09_HUMANkinase -> substrateRegPhos
MK09_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANELK3_HUMANkinase -> substrateHPRD; RegPhos
CSK21_HUMANMK09_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANB2L11_HUMANkinase -> substrateRegPhos
RET_HUMANMK09_HUMANkinase -> substrateHPRD; RegPhos
MK09_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANH33_HUMANkinase -> substrateHPRD; RegPhos
MK09_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANNFAC3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANRRN3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
MP2K4_HUMANMK09_HUMANkinase -> substrateHPRD; RegPhos; NetPath; Robert H Newman (2013)
MK09_HUMANM3K8_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANMAPK5_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANMEF2A_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANJUN_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
MK09_HUMANID1_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
MK09_HUMANMPIP3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANJIP1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANATF2_HUMANkinase -> substrateRegPhos
MK09_HUMANFOS_HUMANkinase -> substrateKEGG
MK09_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANSPT5H_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04380Osteoclast differentiation
hsa05200Pathways in cancer
hsa05169Epstein-Barr virus infection
hsa04912GnRH signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05168Herpes simplex infection
hsa05164Influenza A
hsa04728Dopaminergic synapse
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa05145Toxoplasmosis
hsa05131Shigellosis
hsa05166HTLV-I infection
hsa04910Insulin signaling pathway
hsa05152Tuberculosis
hsa04920Adipocytokine signaling pathway
hsa05212Pancreatic cancer
hsa04622RIG-I-like receptor signaling pathway
hsa05160Hepatitis C
hsa04310Wnt signaling pathway
hsa04510Focal adhesion
hsa04664Fc epsilon RI signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04141Protein processing in endoplasmic reticulum
hsa04010MAPK signaling pathway
hsa04660T cell receptor signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04722Neurotrophin signaling pathway
hsa05133Pertussis
hsa04723Retrograde endocannabinoid signaling
hsa04621NOD-like receptor signaling pathway
hsa05132Salmonella infection
hsa05210Colorectal cancer
hsa04930Type II diabetes mellitus
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045087innate immune responseTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0010744positive regulation of macrophage derived foam celIMPbiological_process
GO:0031396regulation of protein ubiquitinationIEAbiological_process
GO:0046686response to cadmium ionIEAbiological_process
GO:2001235positive regulation of apoptotic signaling pathwayIEAbiological_process
GO:0007254JNK cascadeIEAbiological_process
GO:0071347cellular response to interleukin-1IEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0007254JNK cascadeIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0007258JUN phosphorylationIEAbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0043280positive regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0031394positive regulation of prostaglandin biosynthetic IEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0042493response to drugIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0034644cellular response to UVIEAbiological_process
GO:0010770positive regulation of cell morphogenesis involvedIEAbiological_process
GO:0009636response to toxinIEAbiological_process
GO:0006950response to stressTASbiological_process
GO:0046328regulation of JNK cascadeIEAbiological_process
GO:0032308positive regulation of prostaglandin secretionIEAbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0032722positive regulation of chemokine productionIEAbiological_process
GO:0008656cysteine-type endopeptidase activator activity invIEAmolecular_function
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0071356cellular response to tumor necrosis factorIEAbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0010033response to organic substanceIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0031435mitogen-activated protein kinase kinase kinase binIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0051770positive regulation of nitric-oxide synthase biosyIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0014075response to amine stimulusIEAbiological_process
GO:0051090regulation of sequence-specific DNA binding transcTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0001836release of cytochrome c from mitochondriaIEAbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0006626protein targeting to mitochondrionIEAbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0044445cytosolic partIEAcellular_component
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0004705JUN kinase activityIEAmolecular_function