Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EF2K_HUMAN
Description:eukaryotic elongation factor-2 kinase [Source:HGNC Symbol;Acc:24615]
Location:chr16 p12.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T340AVNQNtKLLQSPhosphoSitePlus
S78GSPANsFHFKEAMPKa2RegPhos
S398LPSSPsSATPHPRKAA1HPRD
S398LPSSPsSATPHPRKAA2HPRD
S366QVRTLsGSRPPPhosphoSitePlus
S416HWPVFsDLDNMPhosphoSitePlus
S396DSLPSsPSSATeEF2KRegPhos
S366RVRTLsGSRPPRPS6KA1HPRD
S396DSLPSsPSSATJNK2RegPhos
S396DSLPSsPSSATJNK1RegPhos
S477EDSLGsSGRVCPhosphoSitePlus; HPRD; phosphoELM
S396DSLPSsPSSATPhosphoSitePlus; phosphoELM
S27GHDGDsDGDSDPhosphoSitePlus; HPRD; RegPhos
S78GSPANsFHFKEAMPKa1RegPhos
S395FDSLPsSPSSAPhosphoSitePlus
S366RVRTLsGSRPPp70S6KRegPhos
S491WNLLNsSRLHLPhosphoSitePlus
S399PSSPSsATPHSPhosphoSitePlus
S366RVRTLsGSRPPp70S6K_groupphosphoELM
S500HLPRAsAVALEPRKACAHPRD
S135LIKMAsQPFGRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S31DSDGDsDDEEGPhosphoSitePlus; HPRD; RegPhos
S366RVRTLsGSRPPRSK3RegPhos
S380PLSENsGDENMPhosphoSitePlus
S78GSPANsFHFKEAMPK_groupphosphoELM; RegPhos
S78GSPANsFHFKEPhosphoSitePlus
S396DSLPSsPSSATp38bRegPhos
S396DSLPSsPSSATp38dRegPhos
S366RVRTLsGSRPPRPS6KB1HPRD
S71SERYSsSGSPARegPhos
S441ENSGDsGYPSEPhosphoSitePlus
S392DVTFDsLPSSPPhosphoSitePlus
S66SNLTKsERYSSPhosphoSitePlus
S366RVRTLsGSRPPAMPK_groupphosphoELM; RegPhos
S366RVRTLsGSRPPp70_groupRegPhos
T401SPSSAtPHSQKPhosphoSitePlus
S377LLRPLsENSGDPhosphoSitePlus
S18VDGGQsPRAGHPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S359EEKCGsPRVRTp38d(MAPK13RegPhos
S396DSLPSsPSSATp38aRegPhos
S500HLPRAsAVALEPKACaRegPhos
Y37DDEEGyFICPIPhosphoSitePlus
Y600TKGFDyLLKAAPhosphoSitePlus; HPRD
S359EEKCGsPQVRTPhosphoSitePlus
S396DSLPSsPSSATMAPK14HPRD
S396DSLPSsPSSATMAPK13HPRD
S396DSLPSsPSSATMAPK8HPRD
S396DSLPSsPSSATMAPK9HPRD
Y468YSNRKyESDEDHPRD; phosphoELM
S366RVRTLsGSRPPPRKACAHPRD
S61VNKYYsNLTKSPhosphoSitePlus
S78GSPANsFHFKEPRKAA2HPRD
S78GSPANsFHFKEPRKAA1HPRD
S72ERYSSsGSPANPhosphoSitePlus; HPRD; phosphoELM
S398LPSSPsSATPHAMPKa2RegPhos
S398LPSSPsSATPHAMPKa1RegPhos
S366RVRTLsGSRPPPKACaRegPhos
S474ESDEDsLGSSGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S359EEKCGsPRVRTMAPK13HPRD; phosphoELM
T353TILRGtEEKCGPhosphoSitePlus
S445DSGYPsEKRGEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S377LLRPLsENSGDMAPKAPK2HPRD; phosphoELM; RegPhos
S377LLRPLsENSGDMAPKAPK5HPRD; RegPhos
S366RVRTLsGSRPPAMPKa2RegPhos
S366RVRTLsGSRPPAMPKa1RegPhos
Y236YIEGKyIKYNSAlpha_kinasePhosphoSitePlus
Y69TKSERySSSGSHPRD; RegPhos
S500HLPRAsAVALEPhosphoSitePlus
S366RVRTLsGSRPPRSK_groupphosphoELM; RegPhos
S366RVRTLsGSRPPPRKAA1HPRD
S366RVRTLsGSRPPPRKAA2HPRD
S359EEKCGsPRVRTp38dRegPhos
S396DSLPSsPSSATp38gRegPhos
T364SPQVRtLSGSRPhosphoSitePlus
Y59SKVNKyYSNLTPhosphoSitePlus
S74YSSSGsPANSFPhosphoSitePlus; HPRD; phosphoELM
Y60KVNKYySNLTKPhosphoSitePlus
S377LLRPLsENSGDMAPKAPK3HPRD; RegPhos
Y443SGDSGyPSEKRPhosphoSitePlus
S70KSERYsSSGSPPhosphoSitePlus; HPRD; RegPhos
S470NRKYEsDEDSLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S398LPSSPsSATPHAMPK_groupphosphoELM; RegPhos
S398LPSSPsSATPHPhosphoSitePlus
T348LQSAKtILRGTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S396DSLPSsPSSATMAPK12HPRD
S396DSLPSsPSSATMAPK11HPRD

Dephosphorylation site
EF2K_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263026Y533*TCGAOvarian Cancer21720365, 18772890
ENSP00000263026T291MGreenman2007Intestines Cancer17344846, 18428421
ENSP00000263026Q632HBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000263026T291MHPIColorectal Cancer17344846

Differential expressed protein
EF2K_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EF2K_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANEF2K_HUMANkinase -> substrateRegPhos
KS6A1_HUMANEF2K_HUMANkinase -> substrateHPRD
KS6A2_HUMANEF2K_HUMANkinase -> substrateRegPhos
EF2K_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANEF2K_HUMANkinase -> substrateHPRD
MAPK5_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
EF2K_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
EF2K_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
EF2K_HUMANTULP4_HUMANkinase -> substrateRobert H Newman (2013)
EF2K_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK3_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
EF2K_HUMANNXF3_HUMANkinase -> substrateRobert H Newman (2013)
EF2K_HUMANEF2_HUMANkinase -> substrateHPRD
AAPK1_HUMANEF2K_HUMANkinase -> substrateHPRD
MK14_HUMANEF2K_HUMANkinase -> substrateHPRD
MK08_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
MAPK2_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
MK12_HUMANEF2K_HUMANkinase -> substrateHPRD
EF2K_HUMANAAPK1_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
MK13_HUMANEF2K_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK11_HUMANEF2K_HUMANkinase -> substrateHPRD
KS6B1_HUMANEF2K_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
AAPK2_HUMANEF2K_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
EF2K_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005524ATP bindingIEAmolecular_function
GO:0006414translational elongationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0046777protein autophosphorylationIDAbiological_process
GO:0031952regulation of protein autophosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0008135translation factor activity, nucleic acid bindingTASmolecular_function
GO:0004686elongation factor-2 kinase activityIEAmolecular_function
GO:0004686elongation factor-2 kinase activityIDAmolecular_function
GO:0005516calmodulin bindingIDAmolecular_function
GO:0005737cytoplasmTAScellular_component
GO:0004672protein kinase activityTASmolecular_function
GO:0006468protein phosphorylationIEAbiological_process


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