| UniProt/SwissProt ID: | RNF14_HUMAN |
| Description: | ring finger protein 14 [Source:HGNC Symbol;Acc:10058] |
| Location: | chr5 q31.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S348 | TYHGVsPCKVT | HPRD; phosphoELM | |
| S348 | TYHGVsPCKVT | IBR | PhosphoSitePlus |
| Dephosphorylation site |
| RNF14_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000348462 | E64K | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000378028 | E64K | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000324956 | N441Y | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000324956 | E64K | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000378027 | E64K | COSMIC | Head and Neck Cancer | 21984974 |
| Differential expressed protein |
| RNF14_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RNF14_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ACVR1_HUMAN | RNF14_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK6_HUMAN | RNF14_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RNF14_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0019787 | small conjugating protein ligase activity | IDA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0050681 | androgen receptor binding | IPI | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0032355 | response to estradiol stimulus | IDA | biological_process |
| GO:0060765 | regulation of androgen receptor signaling pathway | IDA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0030521 | androgen receptor signaling pathway | NAS | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | NAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IDA | biological_process |
| GO:0003713 | transcription coactivator activity | TAS | molecular_function |