Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RNF14_HUMAN
Description:ring finger protein 14 [Source:HGNC Symbol;Acc:10058]
Location:chr5 q31.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S348TYHGVsPCKVTHPRD; phosphoELM
S348TYHGVsPCKVTIBRPhosphoSitePlus

Dephosphorylation site
RNF14_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000348462E64KCOSMICHead and Neck Cancer21984974
ENSP00000378028E64KCOSMICHead and Neck Cancer21984974
ENSP00000324956N441YBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000324956E64KCOSMICHead and Neck Cancer21984974
ENSP00000378027E64KCOSMICHead and Neck Cancer21984974

Differential expressed protein
RNF14_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RNF14_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ACVR1_HUMANRNF14_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANRNF14_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RNF14_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0019787small conjugating protein ligase activityIDAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0050681androgen receptor bindingIPImolecular_function
GO:0005634nucleusIDAcellular_component
GO:0016567protein ubiquitinationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0032355response to estradiol stimulusIDAbiological_process
GO:0060765regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIDAbiological_process
GO:0003713transcription coactivator activityTASmolecular_function


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