Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACVR1_HUMAN
Description:activin A receptor, type I [Source:HGNC Symbol;Acc:171]
Location:chr2 q24.1
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T496IKKTLtKIDNSPhosphoSitePlus
S501TKIDNsLDKLKPhosphoSitePlus
S226EVWRGsWQGENPkinasePhosphoSitePlus
T494LRIKKtLTKIDPkinasePhosphoSitePlus

Dephosphorylation site
ACVR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000387273P115SGreenman2007Skin Cancer17344846, 18428421
ENSP00000263640P115SGreenman2007Skin Cancer17344846, 18428421
ENSP00000387127P115SGreenman2007Skin Cancer17344846, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000405004Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.4315169874

Hyperphosphorylation site
ACVR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BMP6_HUMANACVR1_HUMANligand -> receptorHPMR
BMP7_HUMANACVR1_HUMANligand -> receptorHPMR
ACVR1_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANSMAD1_HUMANkinase -> substrateHPRD
ACVR1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANMCM5_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANRIPK3_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANRXRG_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANRNF14_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANZBT44_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANGA45A_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANDNJB2_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANSMAD2_HUMANkinase -> substrateKEGG
ACVR1_HUMANE2F3_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANORC1_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANSMAD3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04350TGF-beta signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIDAmolecular_function
GO:0017046peptide hormone bindingNASmolecular_function
GO:0001702gastrulation with mouth forming secondIEAbiological_process
GO:0001707mesoderm formationIEAbiological_process
GO:0003183mitral valve morphogenesisIMPbiological_process
GO:0048185activin bindingIEAmolecular_function
GO:0032926negative regulation of activin receptor signaling IMPbiological_process
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0032924activin receptor signaling pathwayIDAbiological_process
GO:0071385cellular response to glucocorticoid stimulusIEAbiological_process
GO:0023014signal transduction by phosphorylationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0061445endocardial cushion cell fate commitmentIMPbiological_process
GO:0060037pharyngeal system developmentIEAbiological_process
GO:0005024transforming growth factor beta-activated receptorIEAmolecular_function
GO:0009790embryo developmentIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0030501positive regulation of bone mineralizationIMPbiological_process
GO:0007369gastrulationIEAbiological_process
GO:0048641regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0005025transforming growth factor beta receptor activity,IEAmolecular_function
GO:0010862positive regulation of pathway-restricted SMAD proIDAbiological_process
GO:0060923cardiac muscle cell fate commitmentIMPbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0016361activin receptor activity, type IIEAmolecular_function
GO:0005887integral to plasma membraneIEAcellular_component
GO:0004675transmembrane receptor protein serine/threonine kiRCAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0019838growth factor bindingIEAmolecular_function
GO:0046332SMAD bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0060389pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0003143embryonic heart tube morphogenesisIMPbiological_process
GO:0016020membraneIEAcellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0001755neural crest cell migrationIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0030278regulation of ossificationIMPbiological_process
GO:0048179activin receptor complexIEAcellular_component
GO:0007498mesoderm developmentIEAbiological_process
GO:0018107peptidyl-threonine phosphorylationIDAbiological_process
GO:0051145smooth muscle cell differentiationIEAbiological_process
GO:0004702receptor signaling protein serine/threonine kinaseIEAmolecular_function
GO:0009968negative regulation of signal transductionIMPbiological_process
GO:0001655urogenital system developmentIEAbiological_process
GO:0050431transforming growth factor beta bindingIEAmolecular_function
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0045669positive regulation of osteoblast differentiationIMPbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0045177apical part of cellIEAcellular_component
GO:0003289atrial septum primum morphogenesisIMPbiological_process
GO:0007281germ cell developmentIEAbiological_process
GO:2000017positive regulation of determination of dorsal ideIDAbiological_process
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0002526acute inflammatory responseIEAbiological_process