Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GA45A_HUMAN
Description:growth arrest and DNA-damage-inducible, alpha [Source:HGNC Symbol;Acc:4095]
Location:chr1 p31.3
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S32LSKALsQRTITRibosomal_L7AePhosphoSitePlus
Y41ITVGVyEAAKLRibosomal_L7AePhosphoSitePlus

Dephosphorylation site
GA45A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360025E100GCOSMICOvarian Cancer21720365

Differential expressed protein
GA45A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GA45A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANGA45A_HUMANkinase -> substrateRobert H Newman (2013)
LATS1_HUMANGA45A_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANGA45A_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANGA45A_HUMANkinase -> substrateRobert H Newman (2013)
TOPK_HUMANGA45A_HUMANkinase -> substrateRobert H Newman (2013)
P53_HUMANGA45A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
GA45A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071479cellular response to ionizing radiationIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007050cell cycle arrestIEAbiological_process
GO:0006281DNA repairTASbiological_process
GO:0007098centrosome cycleIEAbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:2000379positive regulation of reactive oxygen species metIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006469negative regulation of protein kinase activityIEAbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0042770signal transduction in response to DNA damageIMPbiological_process


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