Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MDM2_HUMAN
Description:Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) [Source:HGNC Symbol;Acc:6973]
Location:chr12 q15
Node attribute:PPI(target); PPI(source); ubiquitination(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y394QESEDySQPSTAblphosphoELM
S401ESEDYsQPSTSATMHPRD
T306DYWKCtSCNEMzf-RanBPPhosphoSitePlus
S121SDSGTsVSENRPhosphoSitePlus
S190KSDSIsLSFDEPhosphoSitePlus
S160RPSTSsRRRAIPhosphoSitePlus
S172RRRAIsETEENAKT1HPRD
S188RHKSDsISLSFAKT_groupRegPhos
S17GAVTTsQIPASPhosphoSitePlus
S166RPSTSsRRRAIAKT1HPRD
S186RKRHKsDSISLAKT_groupRegPhos
S166RRRAIsETEENDAPK3phosphoELM; RegPhos
S407SIIYSsQEDVKPhosphoSitePlus
S307YWKCTsCNEMNzf-RanBPPhosphoSitePlus
T365PDCKKtIVNDSPhosphoSitePlus
S166RRRAIsETEENAKT_groupRegPhos
S342DKGEIsEKAKLPhosphoSitePlus
S246VSDQFsVEFEVPhosphoSitePlus; phosphoELM; RegPhos
T288AGESDtDSFEEPhosphoSitePlus
S269EGQELsDEDDEPhosphoSitePlus; phosphoELM; RegPhos
S429ESVESsLPLNAPhosphoSitePlus
S407SIIYSsQEDVKATRphosphoELM; RegPhos
S157LVSRPsTSSRRPhosphoSitePlus; phosphoELM; RegPhos
S172ETEENsDELSGAKT1RegPhos
S395ESEDYsQPSTSATMphosphoELM; RegPhos
S290ESDTDsFEEDPPhosphoSitePlus
S192DSISLsFDESLPhosphoSitePlus
S425QDKEEsVESSLPhosphoSitePlus
Y394QESEDySQPSTPhosphoSitePlus
T168RAISEtEENSDPhosphoSitePlus
T419FEREEtQDKEEPhosphoSitePlus
S401QPSTSsSIIYSATMRegPhos
Y400QESEDySQPSTABL1HPRD
S395ESEDYsQPSTSPhosphoSitePlus
S240WLDQDsVSDQFPhosphoSitePlus; phosphoELM; RegPhos
S386KITQAsQSQESPhosphoSitePlus
Y276EDDEVyQVTVYPhosphoSitePlus
S388TQASQsQESEDPhosphoSitePlus
S192RKRHKsDSISLAKT1HPRD
S188RHKSDsISLSFPKB_groupphosphoELM
S350AKLENsTQAEEPhosphoSitePlus
Y405SSSIIySSQEDPhosphoSitePlus
S172ETEENsDELSGPhosphoSitePlus
S242DQDSVsDQFSVPhosphoSitePlus; phosphoELM; RegPhos
S186RKRHKsDSISLPhosphoSitePlus
S373NDSREsCVEENPhosphoSitePlus
S176NSDELsGERQRPhosphoSitePlus
S186RKRHKsDSISLPKB_groupphosphoELM
S406SSIIYsSQEDVPhosphoSitePlus
S166RRRAIsETEENPhosphoSitePlus
S188RHKSDsISLSFPhosphoSitePlus
S229LDAGVsEHSGDPhosphoSitePlus
S118QESSDsGTSVSPhosphoSitePlus
S166RRRAIsETEENPKB_groupphosphoELM
S256VESLDsEDYSLPhosphoSitePlus
Y60FYLGQyIMTKRSWIBPhosphoSitePlus
S262EDYSLsEEGQEPhosphoSitePlus; phosphoELM; RegPhos
T279EVYQVtVYQAGPhosphoSitePlus
S220STGTPsNPDLDPhosphoSitePlus
S253EFEVEsLDSEDPhosphoSitePlus
S192DSISLsFDESLAKT1RegPhos
Y394QESEDySQPSTABL1RegPhos
S260DSEDYsLSEEGPhosphoSitePlus; phosphoELM; RegPhos
S286YQAGEsDTDSFPhosphoSitePlus
T351KLENStQAEEGPhosphoSitePlus

Dephosphorylation site
MDM2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000417281Y287HTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
MDM2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S166SSRRRAIsETEENSDkidney cancer19920202PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
DAPK3_HUMANMDM2_HUMANkinase -> substrateRegPhos
KS6B1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KCC1B_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
NEK9_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ABL1_HUMANMDM2_HUMANkinase -> substrateHPRD; RegPhos
ATR_HUMANMDM2_HUMANkinase -> substrateRegPhos
TBK1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
STK38_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANMDM2_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMDM2_HUMANkinase -> substrateRegPhos
NEK3_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
ATM_HUMANMDM2_HUMANkinase -> substrateRegPhos
MDM2_HUMANANDR_HUMANubiquitinationNetPath
MDM2_HUMANRB_HUMANotherKEGG
P53_HUMANMDM2_HUMANotherKEGG
CD2A2_HUMANMDM2_HUMANotherKEGG
MDM4_HUMANMDM2_HUMANotherKEGG
MDM2_HUMANP53_HUMANotherKEGG
P53_HUMANMDM2_HUMANTF -> target geneKEGG
P53_HUMANMDM2_HUMANTF -> target geneTRANSFAC
P63_HUMANMDM2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05218Melanoma
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa04110Cell cycle
hsa05202Transcriptional misregulation in cancer
hsa04115p53 signaling pathway
hsa05169Epstein-Barr virus infection
hsa05214Glioma
hsa04120Ubiquitin mediated proteolysis
hsa05203Viral carcinogenesis
hsa04144Endocytosis
hsa05219Bladder cancer
hsa05215Prostate cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005730nucleolusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0045787positive regulation of cell cycleIEAbiological_process
GO:0009636response to toxinIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0048545response to steroid hormone stimulusIEAbiological_process
GO:0042975peroxisome proliferator activated receptor bindingIEAmolecular_function
GO:0018205peptidyl-lysine modificationIMPbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0016604nuclear bodyIDAcellular_component
GO:0034504protein localization to nucleusIDAbiological_process
GO:0045184establishment of protein localizationIDAbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0042493response to drugIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0046677response to antibioticIEPbiological_process
GO:0016567protein ubiquitinationIDAbiological_process
GO:0006461protein complex assemblyIDAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0006977DNA damage response, signal transduction by p53 clIMPbiological_process
GO:0070301cellular response to hydrogen peroxideIEAbiological_process
GO:0002039p53 bindingIEAmolecular_function
GO:0004842ubiquitin-protein ligase activityIMPmolecular_function
GO:0042787protein ubiquitination involved in ubiquitin-depenIMPbiological_process
GO:0010629negative regulation of gene expressionIEAbiological_process
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0071236cellular response to antibioticIEAbiological_process
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0005737cytoplasmIMPcellular_component
GO:0042176regulation of protein catabolic processIDAbiological_process
GO:0004842ubiquitin-protein ligase activityIEAmolecular_function
GO:0005654nucleoplasmIDAcellular_component
GO:0042787protein ubiquitination involved in ubiquitin-depenIDAbiological_process
GO:0009743response to carbohydrate stimulusIEAbiological_process
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0046827positive regulation of protein export from nucleusIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0071301cellular response to vitamin B1IEAbiological_process
GO:0043154negative regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0010039response to iron ionIEAbiological_process
GO:0030163protein catabolic processIEAbiological_process
GO:0016567protein ubiquitinationIEAbiological_process
GO:0045202synapseIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0043278response to morphineIEAbiological_process
GO:0097110scaffold protein bindingIEAmolecular_function
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0043234protein complexIDAcellular_component
GO:0071157negative regulation of cell cycle arrestIDAbiological_process
GO:0032436positive regulation of proteasomal ubiquitin-depenIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0007089traversing start control point of mitotic cell cycIEAbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0071494cellular response to UV-CIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0045472response to etherIEAbiological_process
GO:0031648protein destabilizationIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0002039p53 bindingIPImolecular_function
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0071391cellular response to estrogen stimulusIEAbiological_process
GO:0071456cellular response to hypoxiaIEPbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0071407cellular response to organic cyclic compoundIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0010955negative regulation of protein processingIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0071229cellular response to acidIEAbiological_process
GO:0071157negative regulation of cell cycle arrestIEAbiological_process
GO:0071312cellular response to alkaloidIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0032026response to magnesium ionIEAbiological_process
GO:0008270zinc ion bindingIDAmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0043518negative regulation of DNA damage response, signalIDAbiological_process
GO:0071375cellular response to peptide hormone stimulusIEAbiological_process